Lind S E, Weitzman S A
Am J Med Sci. 1985 Sep;290(3):107-10. doi: 10.1097/00000441-198509000-00005.
Endocrine tumors may produce secondary or "ectopic" hormones that cause paraneoplastic syndromes. Such syndromes may be confused with more common complications related to a patient's tumor, and thus escape detection and appropriate treatment. The secondary hormone secretion responsible for these syndromes often occurs late in the course of such diseases and presents in an insidious manner. Two patients are presented that illustrate these points. The first, a woman with medullary carcinoma of the thyroid (MCT), developed a syndrome secondary to ACTH secretion that was confused initially with the changes caused by the massive diarrhea that accompanies MCT. The second, a man with malignant glucagonoma, is the first with this disease to have developed symptomatic hyperinsulinemia as a late complication. We stress the clinical courses of these patients and note that treatment of these syndromes may improve the quality of patients' lives.
内分泌肿瘤可能会产生继发性或“异位”激素，从而导致副肿瘤综合征。此类综合征可能会与患者肿瘤相关的更常见并发症相混淆，进而无法得到检测和适当治疗。导致这些综合征的继发性激素分泌通常在这类疾病病程的晚期出现，且表现隐匿。本文介绍了两名患者以说明这些情况。首例患者为一名患有甲状腺髓样癌（MCT）的女性，因促肾上腺皮质激素分泌而出现一种综合征，最初被误诊为MCT伴发的大量腹泻所引起的变化。第二例患者为一名患有恶性胰高血糖素瘤的男性，是首例因这种疾病在晚期出现有症状的高胰岛素血症的患者。我们着重介绍了这些患者的临床病程，并指出对这些综合征的治疗可能会改善患者的生活质量。
