Barron J, Sandman C A
Am J Ment Defic. 1985 Sep;90(2):124-9.
The relationships among "paradoxical" excitement to sedative--hypnotic medication, self-injurious behavior, and perinatal trauma were evaluated. Mentally retarded patients were classified as either paradoxical or normal responders to sedative-hypnotics. Paradoxical responders to these medications have a lower MA, a history of perinatal trauma, self-injurious behavior (SIB), and aggressive behavior when compared to normal responders. These findings confirmed and extended previous reports that a type of SIB may be indexed by paradoxical response to sedative-hypnotics. Results also suggested that perinatal trauma may be of etiological importance in the development of SIB. Because perinatal trauma or fetal distress results in excessive levels of B-endorphin, in utero, an impaired endogenous opiate system may be a critical factor maintaining a syndrome of SIB. Thus, these data may indicate psychopharmacological markers of SIB that may have both treatment and etiological significance.
对镇静催眠药物的“矛盾性”兴奋、自伤行为和围产期创伤之间的关系进行了评估。智力迟钝患者被分类为对镇静催眠药有矛盾反应或正常反应者。与正常反应者相比，这些药物的矛盾反应者有较低的智力年龄、围产期创伤史、自伤行为（SIB）和攻击行为。这些发现证实并扩展了先前的报告，即一种自伤行为可能以对镇静催眠药的矛盾反应为指标。结果还表明，围产期创伤在自伤行为的发展中可能具有病因学重要性。因为围产期创伤或胎儿窘迫会导致子宫内β-内啡肽水平过高，内源性阿片系统受损可能是维持自伤行为综合征的关键因素。因此，这些数据可能表明自伤行为的精神药理学标志物，其可能具有治疗和病因学意义。
