Sachan Pushp Lata, Singh Meenakshi, Patel Munna Lal, Sachan Rekha
Department of Physiology, Career Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Department of Obstetrics and Gynaecology, King George Medical University, Lucknow, Uttar Pradesh, India.
Asia Pac J Oncol Nurs. 2018 Jul-Sep;5(3):337-341. doi: 10.4103/apjon.apjon_15_18.
The objective of the study is to evaluate the use of the Pap smear screening method for detection of precancerous lesions.
All women who visited the outpatient gynecology clinic of the Department of Obstetrics and Gynaecology at King Georges Medical University, Lucknow, UP, India, over 1 year for different clinical problems were recruited for the study. A total of 1650 women who were sexually active and over 21 years of age were enrolled in the study. A clinical examination, an examination per speculum, and a vaginal examination were performed and a history taken for all women. A Pap smear was used for all women to screen for cervical cancer. The smear was obtained using an Ayre spatula and spread over a marked glass slide, which was placed in 95% ethyl alcohol and sent to the Department of Pathology for cytopathological examination. All data were recorded using a predetermined pro forma. Women who had visible malignant cervical lesions were excluded from the study.
Most women were in the age range of 30-50 years and multiparous. Vaginal discharge was the most common complaint, occurring in 36.96% of the women. An irregular menstrual cycle was the complaint of 12.78% and abdominal pain of 25.63% of women, while 15.15% were asymptomatic. The Pap smear test of 93.57% of the women was adequately taken, while 6.42% of the individuals had an inadequate sample. The test was negative for malignancy in 48.84%, and 42.66% had infection or inflammation. Atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), and high-grade squamous intraepithelial lesion (HSIL) were detected in 2.90%, 5.09%, and 0.48%, respectively. Women with Pap tests positive for ASCUS, LSIL, and HSIL underwent a colposcopy and guided biopsy.
Women with an abnormal Pap test should undergo a colposcopy, and those with abnormal colposcopy findings should be advised to undergo a biopsy. A Pap smear is simple, noninvasive, cost-effective, and easy to perform for detection of precancerous lesions in a gynecological patient.
本研究的目的是评估巴氏涂片筛查方法用于检测癌前病变的情况。
招募了印度北方邦勒克瑙市乔治国王医科大学妇产科门诊妇科诊所1年内因不同临床问题前来就诊的所有女性参与研究。共有1650名性活跃且年龄超过21岁的女性纳入研究。对所有女性进行了临床检查、窥器检查和阴道检查，并采集了病史。所有女性均采用巴氏涂片进行宫颈癌筛查。涂片使用艾yre刮匙获取，涂抹在有标记的载玻片上，放入95%乙醇中，然后送至病理科进行细胞病理学检查。所有数据均使用预先设定的表格记录。有明显宫颈恶性病变的女性被排除在研究之外。
大多数女性年龄在30 - 50岁之间且多产。阴道分泌物异常是最常见的主诉，占女性的36.96%。月经周期不规律占12.78%，腹痛占25.63%，而15.15%的女性无症状。93.57%的女性巴氏涂片检查样本采集充分，而6.42%的个体样本采集不充分。检测结果恶性为阴性的占48.84%，有感染或炎症的占42.66%。分别检测到意义不明确的非典型鳞状细胞（ASCUS）、低级别鳞状上皮内病变（LSIL）和高级别鳞状上皮内病变（HSIL）的比例为2.90%、5.09%和0.48%。巴氏试验ASCUS、LSIL和HSIL呈阳性的女性接受了阴道镜检查和引导活检。
巴氏试验异常的女性应接受阴道镜检查，阴道镜检查结果异常的女性应建议进行活检。巴氏涂片对于妇科患者癌前病变的检测简单、无创、经济有效且易于操作。
