Shallom J M, Katyare S S
Biochem Pharmacol. 1985 Oct 1;34(19):3445-9. doi: 10.1016/0006-2952(85)90716-6.
Effects of prolonged in vivo treatment with nicotine on synaptosomal ATPase activity in rat brain were examined by employing doses of nicotine (0.02 and 0.04 mg/ml in the drinking water) which simulated intake by moderate and heavy smokers. Under these conditions the "low" dose of nicotine resulted in increased body weight whereas "high" dose of nicotine inhibited weight gain. Examination of synaptosomal ATPase activities revealed a dose and time dependent stimulatory/inhibitory effect. With "low" dose of nicotine, maximum stimulatory effect on ATPase activity was seen at the end of the 3rd week, while "high" dose stimulated the enzyme activities maximally by the 2nd week itself; further treatment up to the 4th week caused inhibition of the ATPase activities (10% to 43% decrease).
通过使用模拟中度和重度吸烟者摄入量的尼古丁剂量（饮用水中为0.02和0.04毫克/毫升），研究了尼古丁长期体内治疗对大鼠脑突触体ATP酶活性的影响。在这些条件下，“低”剂量的尼古丁导致体重增加，而“高”剂量的尼古丁抑制体重增加。突触体ATP酶活性的检测显示出剂量和时间依赖性的刺激/抑制作用。使用“低”剂量的尼古丁时，在第3周结束时对ATP酶活性有最大刺激作用，而“高”剂量在第2周时就使酶活性最大程度地受到刺激；持续治疗至第4周会导致ATP酶活性受到抑制（降低10%至43%）。
