Moran Eye Center.
Duke University Medical Center, Durham, NC.
J Glaucoma. 2018 Jul;27 Suppl 1:S75-S77. doi: 10.1097/IJG.0000000000000936.
The Utah Project on Exfoliation Syndrome (UPEXS) study was created to investigate the association between exfoliation syndrome (XFS) and systemic disorders or pathologies. The study utilizes the resources of the Utah Population Database, which is linked to the Utah genealogy, a compilation of large pedigrees extending back 3 to ≥11 generations, representing most families in the state. These family members medical and health records are linked to vital records and can be used effectively to identify familial clustering of disorders, like XFS, with comorbid diseases or health-related data. There is growing evidence that XFS patients have an increased risk for systemic disorders that may reflect the systemic tissue involvement of this disease. Epidemiologic studies of individuals with XFS have reported an increased risk of various pathologies that have abnormalities in extracellular matrix metabolism and repair. For this reason, the UPEXS has focused on disorders that involve the extracellular matrix in general and elastin specifically, such as pelvic organ prolapse, atrial fibrillation, inguinal hernias, and chronic obstructive pulmonary disease. In this paper we present our results from the analysis of pelvic organ prolapse, as well as, preliminary data for atrial fibrillation.
犹他症候群研究计划（UPEXS）成立的目的在于调查剥脱症候群（XFS）与全身性疾病或病理之间的关联。该研究利用犹他州人口资料库的资源，该资料库与犹他族谱相连结，该族谱是一个可追溯至 3 至≥11 代的大型家谱汇编，代表了该州的大多数家庭。这些家族成员的医疗和健康记录与生命记录相关联，可有效地用于识别像 XFS 这样的疾病家族聚集性，以及合并症或与健康相关的数据。越来越多的证据表明，XFS 患者有发生全身性疾病的风险增加，这可能反映了这种疾病对全身组织的影响。对 XFS 个体的流行病学研究报告称，各种病理学的风险增加，这些病理学在细胞外基质代谢和修复方面存在异常。出于这个原因，UPEXS 专注于一般涉及细胞外基质和弹性蛋白的疾病，例如盆腔器官脱垂、心房颤动、腹股沟疝和慢性阻塞性肺疾病。在本文中，我们展示了我们对盆腔器官脱垂的分析结果，以及心房颤动的初步数据。
