Fonseca Maria João, Severo Milton, Lawlor Debbie A, Barros Henrique, Santos Ana Cristina
EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas n° 135, 4050-600, Porto, Portugal.
Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal.
BMC Pediatr. 2018 Jul 2;18(1):211. doi: 10.1186/s12887-018-1184-x.
Newborn weight change (NWC) in the first 4 days represents short-term adaptations to external environment. It may be a key developmental period for future cardio-metabolic health, but this has not been explored. We aimed to determine the associations of NWC with childhood cardio-metabolic traits.
As part of Generation XXI birth cohort, children were recruited in 2005/2006 at all public units providing obstetrical and neonatal care in Porto. Birthweight was abstracted from clinical records and postnatal anthropometry was obtained by trained examiners during hospital stay. NWC was calculated as ((minimum weight - birthweight)/birthweight) × 100. At age 4 and 7, children were measured and had a fasting blood sample collected. Fasting glucose, LDL-cholesterol, triglycerides, waist circumference, systolic and diastolic blood pressure were evaluated. This study included 312 children with detailed information on growth in very early life and subsequent cardio-metabolic measures. Path analysis was used to compute adjusted regression coefficients and 95% confidence intervals.
NWC was not associated with any cardio-metabolic traits at ages 4 or 7. Strong associations were observed between each cardio-metabolic trait at 4 with the same trait at 7 years. The strongest associations were found for waist circumference [0.725 (0.657; 0.793)] and LDL-cholesterol [0.655 (0.575; 0.735)].
No evidence that NWC is related to childhood cardio-metabolic traits was found, suggesting that NWC should be faced in clinical practice as a short-term phenomenon, with no medium/long term consequences, at least in cardio-metabolic health. Our results show strong tracking correlations in cardio-metabolic traits during childhood.
出生后前4天的新生儿体重变化（NWC）代表了对外部环境的短期适应。这可能是未来心脏代谢健康的关键发育时期，但尚未得到探索。我们旨在确定NWC与儿童心脏代谢特征之间的关联。
作为二十一世纪出生队列研究的一部分，2005/2006年在波尔图所有提供产科和新生儿护理的公共单位招募了儿童。出生体重从临床记录中提取，产后人体测量由经过培训的检查人员在住院期间进行。NWC的计算方法为（（最低体重 - 出生体重）/出生体重）×100。在4岁和7岁时，对儿童进行测量并采集空腹血样。评估空腹血糖、低密度脂蛋白胆固醇、甘油三酯、腰围、收缩压和舒张压。本研究纳入了312名儿童，他们具有生命早期生长和随后心脏代谢指标的详细信息。采用路径分析计算调整后的回归系数和95%置信区间。
NWC与4岁或7岁时的任何心脏代谢特征均无关联。观察到4岁时的每种心脏代谢特征与7岁时的相同特征之间存在强关联。腰围[0.725（0.657；0.793）]和低密度脂蛋白胆固醇[0.655（0.575；0.735）]的关联最强。
未发现NWC与儿童心脏代谢特征相关的证据，这表明在临床实践中应将NWC视为一种短期现象，至少在心脏代谢健康方面没有中长期后果。我们的结果显示儿童期心脏代谢特征存在强追踪相关性。
