Mascarenhas Luis Paulo Gomes, Leite Neiva, Titski Ana Cláudia C Kapp, Brito Lilian Messias Sampaio, Boguszewski Margaret C S
J Pediatr Endocrinol Metab. 2015 Jan;28(1-2):125-31. doi: 10.1515/jpem-2013-0450.
Evaluation of lipid profile in children and adolescents is important for early diagnosis of dyslipidemias. Physiological changes might be observed in the concentration of the lipid profile components, according to the stage of sexual maturation.
To evaluate the variation in lipid and lipoprotein concentrations in boys during puberty.
The sample consisted of 570 male adolescents with ages between 10 and 17 years. Weight, height, and body mass index (BMI) were assessed. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) were determined by the enzymatic method, and low-density lipoprotein cholesterol (LDL-C) was calculated. Puberty was classified according to Tanner references. The percentile criterion was adopted for the distribution and identification of lipoprotein levels. The analysis of variance and description tests with p<0.05 was applied.
Participants had similar BMI z-score and physical activity habits in all groups. A significant reduction in TC and HDL-C concentrations between the start and end of puberty was observed. LDL-C levels rose during stage 3 of development, decreasing at the end of the pubertal process. TG levels did not change significantly with pubertal status.
Lipid and lipoprotein concentrations tend to undergo changes during puberty in boys. The use of percentile values can be very useful to track variations in lipid and lipoprotein levels during the maturation process.
评估儿童和青少年的血脂谱对于血脂异常的早期诊断很重要。根据性成熟阶段，可能会观察到血脂谱成分浓度的生理变化。
评估青春期男孩血脂和脂蛋白浓度的变化。
样本包括570名年龄在10至17岁之间的男性青少年。评估体重、身高和体重指数（BMI）。采用酶法测定总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG），并计算低密度脂蛋白胆固醇（LDL-C）。根据坦纳参考标准对青春期进行分类。采用百分位数标准进行脂蛋白水平的分布和识别。应用方差分析和p<0.05的描述性检验。
所有组的参与者BMI z评分和体育活动习惯相似。青春期开始和结束时，TC和HDL-C浓度显著降低。LDL-C水平在发育第3阶段上升，在青春期结束时下降。TG水平随青春期状态无显著变化。
青春期男孩的血脂和脂蛋白浓度往往会发生变化。使用百分位数对于追踪成熟过程中血脂和脂蛋白水平的变化非常有用。
