Ayele Biniyam Alemayehu, Yifru Yared Mamushet
Department of Neurology, College of Health Science, Addis Ababa Univeristy, PO BOX: 6396, Addis Ababa, Ethiopia.
BMC Neurol. 2018 Jul 2;18(1):95. doi: 10.1186/s12883-018-1095-3.
Migraine headache is a neurologic disorder which mainly affects younger and productive segment of population. Migraine not only causes pain; but also affects quality of life in terms of low productivity and economic loss. The main aim of this study was to examine migraine-related disability, co-morbid depression, and relationship between the two.
A cross-sectional study was conducted among migraineurs who visited two neurology referral clinics. The study was conducted between June 1st 2016 to December 302016. Migraine disability assessment score [MIDAS] and patient health questionnaire [PHQ-9] were used to assess disability and depression, respectively.
A total of 70 patients participated in the study. Fifty-three (74.3%) of our study participants were women. Fifty one (72.9%) study participants were between age group 20-40 years. Migraine without aura was the most common subtype (70%); migraine with aura accounted for the other 28.6%. The mean (± SD) headache frequency and intensity was 23.4 ± 14.9 days and 7.4 ± 1.2 respectively. Major depressive disorder was common in this group (41.4%). The mean MIDAS and PHQ-9 scores were 46.7 ± 30 and 9.2 ± 4.4 respectively. More than two-thirds (74.3%) of our participants had severe disability. We found a statistically significant correlation between migraine-related disability and co morbid depression among our participants(r = 0.318, p-value = 0.007).
The positive correlation observed between migraine-related disability and co-morbid depression warrant routine screening and treatment of disability and depression in migraineurs; In addition, the observed high degree of disability among our participants may indicate sub optimal treatment of these patients.
偏头痛是一种神经系统疾病，主要影响年轻且具有生产力的人群。偏头痛不仅会引起疼痛，还会在生产力低下和经济损失方面影响生活质量。本研究的主要目的是检查与偏头痛相关的残疾、共病性抑郁症以及两者之间的关系。
对前往两家神经科转诊诊所就诊的偏头痛患者进行了一项横断面研究。该研究于2016年6月1日至2016年12月30日进行。分别使用偏头痛残疾评估评分[MIDAS]和患者健康问卷[PHQ-9]来评估残疾和抑郁症。
共有70名患者参与了研究。我们的研究参与者中有53名（74.3%）为女性。51名（72.9%）研究参与者年龄在20-40岁之间。无先兆偏头痛是最常见的亚型（70%）；有先兆偏头痛占另外28.6%。头痛的平均（±标准差）频率和强度分别为23.4±14.9天和7.4±1.2。重度抑郁症在该组中很常见（41.4%）。MIDAS和PHQ-9的平均得分分别为46.7±30和9.2±4.4。超过三分之二（74.3%）的参与者有严重残疾。我们发现参与者中与偏头痛相关的残疾和共病性抑郁症之间存在统计学上的显著相关性（r = 0.318，p值 = 0.007）。
在偏头痛相关残疾和共病性抑郁症之间观察到的正相关值得对偏头痛患者的残疾和抑郁症进行常规筛查和治疗；此外，我们参与者中观察到的高度残疾可能表明这些患者的治疗效果欠佳。
