药物性肝损伤患者磁共振胆管成像的硬化性胆管炎样改变。
Sclerosing Cholangitis-Like Changes on Magnetic Resonance Cholangiography in Patients With Drug Induced Liver Injury.
机构信息
Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.
Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.
出版信息
Clin Gastroenterol Hepatol. 2019 Mar;17(4):789-790. doi: 10.1016/j.cgh.2018.06.035. Epub 2018 Jun 30.
Abstract
Drug-induced liver injury can lead to changes of the biliary tree that resemble sclerosing cholangitis. These changes can be seen on magnetic resonance cholangiopancreatography. Idiosyncratic drug-induced liver injury (DILI) has a variable presentation including cholestatic liver injury, in which case magnetic resonance imaging (MRI) is often performed to exclude pancreaticobiliary causes of obstruction. Sclerosing cholangitis (SC)-like changes on imaging have been described anecdotally with DILI. A recent study of 25 consecutive, unselected DILI patients found that 10% had SC-like changes on magnetic resonance cholangiopancreatography (MRCP). The aim of the current study was to identify the clinical features of patients enrolled in the U.S. Drug Induced Liver Injury Network (DILIN) prospective study who had SC-like changes on MRCP.
摘要
药物性肝损伤可导致胆管树发生类似于硬化性胆管炎的改变。这些改变可在磁共振胰胆管成像（MRCP）上观察到。特发性药物性肝损伤（DILI）的表现具有变异性，包括胆汁淤积性肝损伤，此时通常进行磁共振成像（MRI）以排除胰胆管阻塞的原因。有报道称，DILI 患者的影像学检查可见类似于硬化性胆管炎的改变。最近一项对 25 例连续、未经选择的 DILI 患者的研究发现，10%的患者在 MRCP 上有类似于硬化性胆管炎的改变。本研究旨在确定美国药物性肝损伤网络（DILIN）前瞻性研究中纳入的 MRCP 上有类似于硬化性胆管炎改变的患者的临床特征。
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