Ryberg B, Pirskanen R
Br Med J (Clin Res Ed). 1985 Sep 28;291(6499):850-1. doi: 10.1136/bmj.291.6499.850.
A man with chronic progressive multiple sclerosis received a 10 day course of treatment with adrenocorticotrophic hormone without beneficial effect. He then received six sessions of plasmapheresis, again without improvement. Treatment with adrenocorticotrophic hormone had no effect on serum antibrain antibody titres, but plasmapheresis virtually eliminated the antibodies from serum and caused a fall in serum IgG concentrations; neither treatment had any effect on the IgG concentration and antibody titre in the cerebrospinal fluid. Treatment with plasmapheresis may fail in patients with multiple sclerosis because it does not remove antibrain antibodies from the intrathecal space.
一名患有慢性进行性多发性硬化症的男子接受了为期10天的促肾上腺皮质激素治疗，但没有效果。随后他又接受了6次血浆置换，病情依然没有改善。促肾上腺皮质激素治疗对血清抗脑抗体滴度没有影响，但血浆置换几乎消除了血清中的抗体，并导致血清IgG浓度下降；两种治疗方法对脑脊液中的IgG浓度和抗体滴度均无影响。血浆置换治疗多发性硬化症患者可能会失败，因为它不能清除鞘内空间的抗脑抗体。
