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多发性硬化症中脑抗体的鞘内和鞘外产生

Intrathecal and extrathecal production of antibrain antibodies in multiple sclerosis.

作者信息

Ryberg B

出版信息

J Neurol Sci. 1980 Oct;48(1):1-8. doi: 10.1016/0022-510x(80)90145-8.

DOI:10.1016/0022-510x(80)90145-8
PMID:7420122
Abstract

Complement-fixing antibrain antibodies of several specificities were titrated in paired serum and CSF samples from 27 MS patients. The results indicated that the antibodies were synthesized on both sides of the blood-brain barrier in proportions that showed a great interindividual variation. It is suggested that this variation applies also to other MS-associated immunoglobulins.

摘要

在27例多发性硬化症(MS)患者的配对血清和脑脊液样本中,对几种具有不同特异性的补体结合抗脑抗体进行了滴定。结果表明,这些抗体在血脑屏障两侧均有合成,其比例存在很大的个体差异。有人认为这种差异也适用于其他与MS相关的免疫球蛋白。

相似文献

1
Intrathecal and extrathecal production of antibrain antibodies in multiple sclerosis.多发性硬化症中脑抗体的鞘内和鞘外产生
J Neurol Sci. 1980 Oct;48(1):1-8. doi: 10.1016/0022-510x(80)90145-8.
2
Immunoglobulin characterization by bacterial absorption of antibrain antibodies in multiple sclerosis.通过细菌吸收抗脑抗体对多发性硬化症中的免疫球蛋白进行表征。
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Multiple specificities of antibrain antibodies in multiple sclerosis and chronic myelopathy.多发性硬化症和慢性脊髓病中抗脑抗体的多种特异性
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Persistence of antibrain antibodies in cerebrospinal fluid during plasmapheresis for multiple sclerosis.在进行血浆置换治疗多发性硬化症期间脑脊液中抗脑抗体的持续存在情况。
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Extra- and intrathecal production of antinerve and antibrain antibodies in Guillain-Barré syndrome: evaluation by an antibody index.吉兰-巴雷综合征中抗神经和抗脑抗体的鞘外和鞘内产生:通过抗体指数进行评估
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A longitudinal study of antibrain antibodies in multiple sclerosis.一项关于多发性硬化症抗脑抗体的纵向研究。
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Complement-fixing antibrain antibodies in multiple sclerosis. Comparison of their occurrence in cerebrospinal fluid and serum.多发性硬化症中的补体结合抗脑抗体。脑脊液和血清中其出现情况的比较。
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The ontogenetic mouse brain model employed in the characterization of antibrain antibodies in multiple sclerosis.用于多发性硬化症抗脑抗体表征的个体发育小鼠脑模型。
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引用本文的文献

1
Abnormalities of serum and plasma components in patients with multiple sclerosis.多发性硬化症患者血清和血浆成分异常。
Clin Biochem. 1985 Feb;18(1):3-13. doi: 10.1016/s0009-9120(85)80016-3.
2
Serum antibodies to peripheral nerve tissue in acute Guillain-Barré syndrome in relation to outcome of plasma exchange.急性吉兰-巴雷综合征患者血清中针对周围神经组织的抗体与血浆置换治疗效果的关系
J Neurol. 1988 May;235(5):285-9. doi: 10.1007/BF00314175.
3
Anti-herpes simplex type 1 activity in IgG subclasses produced systemically and intrathecally in patients with herpes encephalitis.
单纯疱疹性脑炎患者全身及鞘内产生的IgG亚类中的抗1型单纯疱疹病毒活性。
J Neurol. 1986 Oct;233(5):289-96. doi: 10.1007/BF00314161.