多发性硬化症中脑抗体的鞘内和鞘外产生
Intrathecal and extrathecal production of antibrain antibodies in multiple sclerosis.
作者信息
Ryberg B
出版信息
J Neurol Sci. 1980 Oct;48(1):1-8. doi: 10.1016/0022-510x(80)90145-8.
PMID:7420122
Abstract
Complement-fixing antibrain antibodies of several specificities were titrated in paired serum and CSF samples from 27 MS patients. The results indicated that the antibodies were synthesized on both sides of the blood-brain barrier in proportions that showed a great interindividual variation. It is suggested that this variation applies also to other MS-associated immunoglobulins.
摘要
在27例多发性硬化症（MS）患者的配对血清和脑脊液样本中，对几种具有不同特异性的补体结合抗脑抗体进行了滴定。结果表明，这些抗体在血脑屏障两侧均有合成，其比例存在很大的个体差异。有人认为这种差异也适用于其他与MS相关的免疫球蛋白。
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