一项关于多发性硬化症抗脑抗体的纵向研究。

A longitudinal study of antibrain antibodies in multiple sclerosis.

作者信息

Ryberg B

出版信息

J Neurol Sci. 1982 May;54(2):263-70. doi: 10.1016/0022-510x(82)90186-1.

Abstract

The presence of complement-fixing antibrain antibodies is a distinctive feature of multiple sclerosis (MS). In a longitudinal study of 35 MS patients antibrain antibody titres in serum were followed for up to 5 years; in 18 of them also CSF titres were determined. No consistent correlations between antibrain antibody titres and clinical events were found. Thus, MS relapses are not caused by a general increase in antibrain antibody titres, and conversely the relapses did not cause a boosting of antibrain antibodies. Significant variations in the local plaque environment are, however, not ruled out by the present results.

摘要

补体结合抗脑抗体的存在是多发性硬化症（MS）的一个显著特征。在一项对35例MS患者的纵向研究中，对血清中的抗脑抗体滴度进行了长达5年的跟踪；其中18例患者还测定了脑脊液中的滴度。未发现抗脑抗体滴度与临床事件之间存在一致的相关性。因此，MS复发不是由抗脑抗体滴度的普遍升高引起的，反之，复发也不会导致抗脑抗体的升高。然而，目前的结果并未排除局部斑块环境存在显著变化的可能性。