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食管同步性三原发性鳞状细胞癌

Synchronous triple squamous cell carcinoma of the esophagus.

作者信息

Petroianu Andy, Sabino Kelly Renata, Nunes Maurício Buzelin

机构信息

Department of Surgery, School of Medicine, Federal University, Minas Gerais, Brazil.

Department of Surgery, School of Medicine, Federal University, Minas Gerais, Brazil.

出版信息

Int J Surg Case Rep. 2018;49:34-36. doi: 10.1016/j.ijscr.2018.05.028. Epub 2018 Jun 15.

DOI:10.1016/j.ijscr.2018.05.028
PMID:29966947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6039883/
Abstract

BACKGROUND

Synchronous multiple primary malignancies of the esophagus and other organs are relatively unusual, but only five articles have published two synchronous cancers, both in the esophagus. This is the first published case of a triple esophageal carcinoma.

CASE REPORT

A 43-year-old man was referred to our hospital with severe progressive dysphagia and epigastric pain for almost one year. Endoscopy and imaging exams revealed three tumors located in upper, middle and lower esophagus. The upper and middle esophageal cancers were irresectable, and the patient was treated with radio- and chemotherapy. He survived 11 months after the diagnosis and died due to severe undernutrition and bilateral pneumonia.

CONCLUSION

In presence of squamous cell carcinoma of the esophagus, propedeutics should be carefully performed in order to verify the occurrence of other synchronous tumors in the esophagus and other organs, mainly head and neck and bronchial regions.

摘要

背景

食管与其他器官的同步多原发性恶性肿瘤相对少见,但仅有5篇文献报道过食管内的2例同步癌。本文首次报道了1例食管三重癌病例。

病例报告

一名43岁男性因严重进行性吞咽困难和上腹部疼痛近一年转诊至我院。内镜检查和影像学检查发现食管上、中、下段各有一个肿瘤。食管上段和中段癌无法切除,患者接受了放疗和化疗。确诊后存活11个月,死于严重营养不良和双侧肺炎。

结论

对于食管鳞状细胞癌患者,应仔细进行前期检查,以确认食管及其他器官(主要是头颈部和支气管区域)是否存在其他同步肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/6039883/05225307ae5b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/6039883/05225307ae5b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/6039883/05225307ae5b/gr1.jpg

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本文引用的文献

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Synchronous triple primary cancers of the pharynx and esophagus.咽和食管的同步三原发癌。
Clin J Gastroenterol. 2017 Jun;10(3):208-213. doi: 10.1007/s12328-017-0734-3. Epub 2017 Mar 17.
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Multiple and synchronous squamous cell carcinoma of the esophagus in a young woman: An example of early and rapid carcinogenesis?一名年轻女性食管多发同步鳞状细胞癌:早期快速致癌的一个例子?
Rev Gastroenterol Mex. 2016 Jul-Sep;81(3):176-8. doi: 10.1016/j.rgmx.2015.09.005. Epub 2016 Mar 2.
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Synchronous second primary cancers in patients with squamous esophageal cancer: clinical features and survival outcome.
食管鳞状细胞癌患者的同步性第二原发性癌症:临床特征与生存结局
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Curative two-stage resection for synchronous triple cancers of the esophagus, colon, and liver: Report of a case.食管、结肠和肝脏同时性三原发癌的根治性二期切除术:1例报告
Int J Surg Case Rep. 2015;13:1-4. doi: 10.1016/j.ijscr.2015.05.032. Epub 2015 May 30.
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Synchronous primary neoplasms detected on 18F-FDG PET in staging of patients with esophageal cancer.在食管癌患者分期中通过18F-FDG PET检测到的同步原发性肿瘤。
J Nucl Med. 2005 Aug;46(8):1321-5.
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Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region.食管及头颈部区域发生多发性鳞状细胞癌的风险。
Carcinogenesis. 2005 May;26(5):1008-12. doi: 10.1093/carcin/bgi035. Epub 2005 Feb 17.
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Multiple primary carcinomas with esophageal squamous cell cancer: clinicopathologic outcome.多原发性癌合并食管鳞状细胞癌:临床病理结果
World J Surg. 2005 Jan;29(1):46-9. doi: 10.1007/s00268-004-7525-y.
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A single institutional phase III trial of preoperative chemotherapy with hyperfractionation radiotherapy plus surgery versus surgery alone for resectable esophageal squamous cell carcinoma.一项单中心III期试验,比较术前化疗联合超分割放疗加手术与单纯手术治疗可切除食管鳞状细胞癌的疗效。
Ann Oncol. 2004 Jun;15(6):947-54. doi: 10.1093/annonc/mdh219.
9
Risk of second primary malignancy after esophagectomy for squamous cell carcinoma of the thoracic esophagus.胸段食管鳞状细胞癌行食管切除术后发生第二原发性恶性肿瘤的风险。
J Clin Oncol. 2003 Dec 1;21(23):4336-41. doi: 10.1200/JCO.2003.12.074.
10
Metachronous triple cancer: esophageal carcinoma 4 years later the synchronous bilateral bronchogenic carcinoma.异时性三原发癌:4年后发生食管癌,同时合并双侧支气管源性癌。
Eur J Cardiothorac Surg. 2003 Aug;24(2):303. doi: 10.1016/s1010-7940(03)00260-4.