Brodie C, Sampson S R
Brain Res. 1985 Nov 11;347(1):121-3. doi: 10.1016/0006-8993(85)90896-0.
The effects of incubation of cultured rat skeletal myotubes in ouabain were studied on the number of [3H]ouabain binding sites and electrogenic component of membrane potential. Ouabain treatment for 2-6 days increased the number of binding sites, resting membrane potential (Em) and the ouabain-sensitive component of Em in the muscle cells. The findings strengthen the idea that Na,K-ATPase has an important role in regulation of Em in cultured skeletal muscle and suggest that Na-K pump inhibition during development may be a regulatory mechanism for cellular synthesis of Na,K-ATPase.
研究了哇巴因对培养的大鼠骨骼肌肌管的作用，观察其对[3H]哇巴因结合位点数量和膜电位电生成成分的影响。用哇巴因处理2 - 6天可增加肌肉细胞中结合位点的数量、静息膜电位（Em）以及Em的哇巴因敏感成分。这些发现强化了钠钾ATP酶在调节培养的骨骼肌Em中起重要作用这一观点，并表明发育过程中钠钾泵的抑制可能是钠钾ATP酶细胞合成的一种调节机制。
