鹅膏蕈氨酸可降低大鼠杏仁核中促甲状腺激素释放激素受体的结合力。

Ibotenic acid decreases thyrotropin-releasing hormone receptor binding in the rat amygdala.

作者信息

Manaker S, Caine S B, Winokur A

出版信息

Brain Res. 1985 Nov 11;347(1):144-8. doi: 10.1016/0006-8993(85)90902-3.

Abstract

Thyrotropin-releasing hormone (TRH) receptor densities in the amygdala were examined with quantitative autoradiography in rats treated with the cellular neurotoxin ibotenic acid (IBO). Microinjections of IBO (10 micrograms) into the right basolateral amygdaloid nucleus (BsA) reduced the concentration of TRH receptors in this nucleus by over 50%, when compared to the contralateral BsA and to vehicle-injected control rats. IBO lesions left amygdaloid terminals intact, as shown by normal levels of presynaptic choline uptake sites. Our results strongly suggest that TRH receptors in the amygdala are predominantly located on cell bodies.

摘要

用定量放射自显影法检测了经细胞神经毒素鹅膏蕈氨酸（IBO）处理的大鼠杏仁核中促甲状腺激素释放激素（TRH）受体的密度。与对侧基底外侧杏仁核（BsA）以及注射溶媒的对照大鼠相比，向右侧基底外侧杏仁核（BsA）微量注射10微克IBO可使该核中TRH受体浓度降低超过50%。如突触前胆碱摄取位点水平正常所示，IBO损伤使杏仁核终末保持完整。我们的结果强烈表明，杏仁核中的TRH受体主要位于细胞体上。