双侧杏仁核基底外侧核注射鹅膏蕈氨酸损伤对大鼠蔗糖假饲反应的影响。

Effect of bilateral ibotenic acid lesions in the basolateral amygdala on the sham feeding response to sucrose in the rat.

作者信息

Siegel A, Joyner K, Smith G P

机构信息

Department of Neuroscience, New Jersey Medical School, Newark 07103.

出版信息

Physiol Behav. 1988;42(3):231-5. doi: 10.1016/0031-9384(88)90075-3.

DOI:10.1016/0031-9384(88)90075-3

PMID:3406149

Abstract

To investigate the role of the basolateral amygdaloid complex in the sham feeding response to sucrose, rats received bilateral ibotenic acid lesions of the basolateral complex and were equipped for sham feeding with implanted chronic gastric cannulas. Rats were also tested on different days with 2.5%, 5%, 10%, and 40% sucrose. After 17 hours of food deprivation, bilateral, amygdaloid-lesioned rats sham fed significantly less 2.5% sucrose than sham operated (control) rats. After no deprivation, amygdaloid-lesioned rats sham fed significantly less 5% sucrose than control rats. Under both deprivation conditions, however, sham intake was a function of sucrose concentrations in both groups of rats and the sham feeding responses of lesioned and control rats to 10% and 40% sucrose were similar. These results demonstrate that cells in the basolateral amygdaloid complex are necessary for the normal sham feeding response to concentrations of sucrose less than 10%, but not for the response to higher concentrations of sucrose.

摘要

为了研究基底外侧杏仁核复合体在对蔗糖假饲反应中的作用，给大鼠双侧注射鹅膏蕈氨酸损毁基底外侧复合体，并植入慢性胃插管以备假饲。还在不同日期用2.5%、5%、10%和40%的蔗糖对大鼠进行测试。在禁食17小时后，双侧杏仁核损毁的大鼠假饲2.5%蔗糖的量显著少于假手术（对照）大鼠。在不禁食的情况下，杏仁核损毁的大鼠假饲5%蔗糖的量显著少于对照大鼠。然而，在两种禁食条件下，两组大鼠的假摄入量均是蔗糖浓度的函数，且损毁组和对照组大鼠对10%和40%蔗糖的假饲反应相似。这些结果表明，基底外侧杏仁核复合体中的细胞对于低于10%浓度蔗糖的正常假饲反应是必需的，但对于更高浓度蔗糖的反应则不是必需的。