Huchcroft S, Gunton P, Bowen T
CMAJ. 1985 Nov 1;133(9):871-5.
A retrospective review of obstetric records for 1979 in two major Calgary hospitals was undertaken to determine the rate of compliance with postpartum Rh isoimmunization prophylaxis in Alberta. The charts of 4528 women ranging in age from 13 to 46 years were reviewed. The prevalence rate of Rh negativity was found to be 16%. Of the 710 Rh-negative women 490 (69%) were eligible to receive Rh immune globulin (RhIG); that is, they had no anti-D antibodies, and the baby/fetus was Rh-positive or Rh-unknown. RhIG had been administered to 93.6% of the eligible women; the compliance rate ranged from 66.7% for obstetric emergencies (i.e., spontaneous abortion, antepartum or early-pregnancy hemorrhage, or ectopic pregnancy) to 98.2% for postpartum diagnoses. In more than half (54.7%) of the women who underwent amniocentesis Rh type was not determined; the implications of this finding are discussed. Although poor compliance with postpartum RhIG administration is not a reason for withholding antepartum administration of RhIG, maximum compliance with the more cost-effective programs should be attained before antepartum programs are fully implemented.
对卡尔加里两家主要医院1979年的产科记录进行了回顾性研究，以确定艾伯塔省产后Rh血型免疫预防的依从率。审查了4528名年龄在13至46岁之间的女性的病历。发现Rh阴性的患病率为16%。在710名Rh阴性女性中，490名（69%）符合接受Rh免疫球蛋白（RhIG）的条件；也就是说，她们没有抗-D抗体，且婴儿/胎儿为Rh阳性或Rh情况不明。符合条件的女性中有93.6%接受了RhIG治疗；依从率从产科紧急情况（即自然流产、产前或早孕出血或异位妊娠）的66.7%到产后诊断的98.2%不等。在接受羊膜穿刺术的女性中，超过一半（54.7%）的Rh血型未确定；讨论了这一发现的影响。尽管产后RhIG给药的依从性差不是产前不给药的理由，但在全面实施产前方案之前，应实现对更具成本效益方案的最大依从性。
