The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale R. Piaggio 34, 56025, Pontedera (Pisa), Italy.
Department for Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Dúbravská cesta 9, 845 41, Bratislava, Slovakia.
Sci Rep. 2018 Jul 2;8(1):9893. doi: 10.1038/s41598-018-28140-3.
Among external stimuli used to trigger release of a drug from a polymeric carrier, ultrasound has gained increasing attention due to its non-invasive nature, safety and low cost. Despite this attention, there is only limited knowledge about how materials available for the preparation of drug carriers respond to ultrasound. This study investigates the effect of ultrasound on the release of a hydrophobic drug, dexamethasone, from poly(2-oxazoline)-based micelles. Spontaneous and ultrasound-mediated release of dexamethasone from five types of micelles made of poly(2-oxazoline) block copolymers, composed of hydrophilic poly(2-methyl-2-oxazoline) and hydrophobic poly(2-n-propyl-2-oxazoline) or poly(2-butyl-2-oxazoline-co-2-(3-butenyl)-2-oxazoline), was studied. The release profiles were fitted by zero-order and Ritger-Peppas models. The ultrasound increased the amount of released dexamethasone by 6% to 105% depending on the type of copolymer, the amount of loaded dexamethasone, and the stimulation time point. This study investigates for the first time the interaction between different poly(2-oxazoline)-based micelle formulations and ultrasound waves, quantifying the efficacy of such stimulation in modulating dexamethasone release from these nanocarriers.
在用于触发药物从聚合物载体中释放的外部刺激物中，由于其非侵入性、安全性和低成本，超声已引起越来越多的关注。尽管受到关注，但对于可用于制备药物载体的材料如何响应超声，人们的了解仍然有限。本研究调查了超声对疏水性药物地塞米松从基于聚（2-恶唑啉）的胶束中释放的影响。使用五种由亲水性聚（2-甲基-2-恶唑啉）和疏水性聚（2-正丙基-2-恶唑啉）或聚（2-丁基-2-恶唑啉-共-2-（3-丁烯基）-2-恶唑啉）组成的嵌段共聚物制备的聚（2-恶唑啉）基胶束，研究了地塞米松的自发和超声介导的释放。通过零级和 Ritger-Peppas 模型拟合释放曲线。根据共聚物的类型、负载的地塞米松的量和刺激时间点，超声使释放的地塞米松的量增加了 6%至 105%。本研究首次调查了不同基于聚（2-恶唑啉）的胶束配方与超声波之间的相互作用，定量评估了这种刺激在调节这些纳米载体中地塞米松释放的效果。
