Department of Clinical Pharmacology, Kumamoto University, 5-1, Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1, Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Oxid Med Cell Longev. 2018 Jun 5;2018:7635274. doi: 10.1155/2018/7635274. eCollection 2018.
Oxidative stress induced by hyperuricemia is closely associated with the renin-angiotensin system, as well as the onset and progression of cardiovascular disease (CVD) and chronic kidney disease (CKD). It is therefore important to reduce oxidative stress to treat hyperuricemia. We previously found that benzbromarone, a uricosuric agent, has a direct free radical scavenging effect . The antioxidant effects of benzbromarone were evaluated via oral administration of benzbromarone for 4 weeks to model rats with angiotensin II- and salt-induced hypertension. Benzbromarone did not alter plasma uric acid levels or blood pressure but significantly reduced the levels of advanced oxidation protein products, which are oxidative stress markers. Furthermore, dihydroethidium staining of the kidney revealed a reduction in oxidative stress after benzbromarone administration. These results suggest that benzbromarone has a direct antioxidant effect and great potential to prevent CVD and CKD.
高尿酸血症引起的氧化应激与肾素-血管紧张素系统以及心血管疾病 (CVD) 和慢性肾病 (CKD) 的发生和进展密切相关。因此，降低氧化应激对于治疗高尿酸血症很重要。我们之前发现，苯溴马隆，一种促尿酸排泄药物，具有直接的自由基清除作用。通过给予苯溴马隆 4 周来评估苯溴马隆的抗氧化作用，以建立血管紧张素 II 和盐诱导的高血压模型大鼠。苯溴马隆没有改变血浆尿酸水平或血压，但显著降低了氧化应激标志物——晚期氧化蛋白产物的水平。此外，肾组织中二氢乙啶染色显示苯溴马隆给药后氧化应激减少。这些结果表明，苯溴马隆具有直接的抗氧化作用，对于预防 CVD 和 CKD 具有很大的潜力。
