在一名患有尼尔森综合征的患者中，服用丙戊酸钠后促肾上腺皮质激素释放因子对垂体促肾上腺皮质激素分泌的刺激未改变。
Unaltered stimulation of pituitary adrenocorticotrophin secretion by corticotrophin-releasing factor following sodium valproate administration in a patient with Nelson's syndrome.
作者信息
Gomi M, Iida S, Itoh Y, Moriwaki K, Kanayama S, Namba M, Tarui S
出版信息
Clin Endocrinol (Oxf). 1985 Aug;23(2):123-7. doi: 10.1111/j.1365-2265.1985.tb00206.x.
Abstract
A 53-year-old woman with Nelson's syndrome was treated with 600 mg sodium valproate daily. Her plasma ACTH was effectively decreased, whilst the response of plasma ACTH to corticotrophin-releasing factor (CRF) was unaltered. The result of the CRF test suggested that sodium valproate, at least in the present patient, acted at the hypothalamic level.
摘要
一名患有尼尔森综合征的53岁女性每天接受600毫克丙戊酸钠治疗。她的血浆促肾上腺皮质激素（ACTH）有效降低，而血浆ACTH对促肾上腺皮质激素释放因子（CRF）的反应未改变。CRF试验结果表明，丙戊酸钠至少在该患者中作用于下丘脑水平。
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