镍催化的杂双环烯烃与内部炔烃的不对称[2+2]环加成反应。
Nickel-Catalyzed Asymmetric [2+2] Cycloaddition Reaction of Hetero-Bicyclic Alkenes with Internal Alkynes.
机构信息
YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Yuehua Street, Kunming, 650500, China.
Key Laboratory of Chemistry in Ethnic Medicinal Resources, Yuehua Street, Kunming, 650500, China.
出版信息
Chem Asian J. 2018 Sep 4;13(17):2431-2434. doi: 10.1002/asia.201800492. Epub 2018 Jul 3.
Enantioselective [2+2] cycloaddition reaction of azabenzonorbornadienes and oxabenzonorbornadienes with internal alkynes has been enabled by a catalyst system comprising Ni(COD) and (R)-SIPHOS-Ph-Mor. This transformation represents the first asymmetric [2+2] cycloaddition reaction of azabenzonorbornadienes with internal alkynes, providing a straightforward method to prepare four-membered carbocycles.
氮杂苯并降蒈二烯和氧杂苯并降蒈二烯与内部炔烃的对映选择性[2+2]环加成反应可以通过包含 Ni(COD)和(R)-SIPHOS-Ph-Mor 的催化剂体系来实现。这种转化代表了氮杂苯并降蒈二烯与内部炔烃的首例不对称[2+2]环加成反应，为制备四元碳环提供了一种直接的方法。
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