Department of Pathology, The University of Michigan, Ann Arbor, MI 48109, USA.
J Physiol. 2018 Sep;596(17):3883-3898. doi: 10.1113/JP275328. Epub 2018 Aug 8.
The single pass, transmembrane proteins of the cadherin family have been appreciated as important proteins that regulate intercellular adhesion. In addition to this critical function, cadherins contribute to important signalling events that control cellular homeostasis. Many examples exist of classical, desmosomal and atypical cadherins participating in the regulation of signalling events that control homeostatic functions in cells. Much of the work on cadherin mediated signalling focuses on classical cadherins or on specific disease states such as pemphigus vulgaris. Cadherin mediated signalling has been shown to play critical roles during development, in proliferation, apoptosis, disease pathobiology and beyond. It is becoming increasingly clear that cadherins operate through a range of molecular mechanisms. The diversity of pathways and cellular functions regulated by cadherins suggests that we have only scratched the surface in terms of the roles that these versatile proteins play in signalling and cellular function.
钙黏蛋白家族的单次跨膜蛋白被认为是调节细胞间黏附的重要蛋白。除了这一关键功能外，钙黏蛋白还参与控制细胞内稳态的重要信号事件。许多经典、桥粒和非典型钙黏蛋白的例子参与了调节控制细胞内稳态功能的信号事件的调控。钙黏蛋白介导的信号转导的大部分工作都集中在经典钙黏蛋白或特发性大疱性表皮松解症等特定疾病状态上。钙黏蛋白介导的信号转导在发育、增殖、凋亡、疾病病理生物学等过程中发挥着关键作用。越来越明显的是，钙黏蛋白通过一系列分子机制发挥作用。钙黏蛋白调节的途径和细胞功能的多样性表明，我们在这些多功能蛋白在信号转导和细胞功能中的作用方面只是略知一二。
