Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, 16802, USA.
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Sci Rep. 2018 Jul 3;8(1):10040. doi: 10.1038/s41598-018-28381-2.
Exposure to social stress is an important risk factor for comorbid affective disorders and problem alcohol use. To better understand mechanisms involved in social stress-induced affective disorder and alcohol use co-morbidity, we studied the effects of adolescent social stress on anxiety- and depression-like behaviors and binge-like ethanol consumption. Male and female C57BL/6J mice were exposed to chronic variable social stress (CVSS) or control conditions throughout adolescence (postnatal days, PND, 25-59) and then tested for anxiety-like behavior in the elevated plus maze and a novel open field environment, or depression-like behavior using the forced swim test on PND 64-66. Mice were then tested for binge-like ethanol consumption using the Drinking-in-the-Dark model. Male and female mice exposed to adolescent CVSS had increased adult anxiety-like behavior and increased locomotor adaptation to a novel environment. Further, CVSS mice consumed significantly more ethanol, but not saccharin, than controls. Despite group differences in both anxiety-like behavior and ethanol consumption, there was no relationship between these outcomes within individual mice. These data suggest that exposure to adolescent social stress is an important risk factor for later alcohol use and affective behaviors, but that social stress does not necessarily dictate co-morbidity of these outcomes.
暴露于社会压力是共患情感障碍和问题性酒精使用的重要风险因素。为了更好地理解社会压力引起的情感障碍和酒精使用共病的相关机制，我们研究了青春期社会压力对焦虑和抑郁样行为以及 binge 样乙醇消费的影响。雄性和雌性 C57BL/6J 小鼠在整个青春期（出生后第 25-59 天）接受慢性可变社会压力（CVSS）或对照条件暴露，然后在高架十字迷宫和新旷场环境中测试焦虑样行为，或在 PND64-66 时使用强迫游泳测试测试抑郁样行为。然后使用暗饮模型测试 binge 样乙醇消耗。暴露于青春期 CVSS 的雄性和雌性小鼠表现出成年焦虑样行为增加和对新环境的运动适应性增加。此外，CVSS 小鼠比对照组消耗了更多的乙醇，但不是蔗糖。尽管在焦虑样行为和乙醇消耗方面存在组间差异，但在个体小鼠中，这些结果之间没有关系。这些数据表明，青春期社会压力暴露是日后饮酒和情感行为的重要风险因素，但社会压力不一定决定这些结果的共病性。
