肿瘤影像学标志物：基础与 MRI 应用。
Imaging biomarkers in oncology: Basics and application to MRI.
机构信息
Biomedical Engineering, School of Biomedical Engineering & Imaging Sciences, King's Health Partners, St Thomas' Hospital, London, UK.
Cancer Imaging, School of Biomedical Engineering & Imaging Sciences, King's College London, King's Health Partners, St Thomas' Hospital, London, UK.
出版信息
J Magn Reson Imaging. 2018 Jul;48(1):13-26. doi: 10.1002/jmri.26058.
UNLABELLED
Cancer remains a global killer alongside cardiovascular disease. A better understanding of cancer biology has transformed its management with an increasing emphasis on a personalized approach, so-called "precision cancer medicine." Imaging has a key role to play in the management of cancer patients. Imaging biomarkers that objectively inform on tumor biology, the tumor environment, and tumor changes in response to an intervention complement genomic and molecular diagnostics. In this review we describe the key principles for imaging biomarker development and discuss the current status with respect to magnetic resonance imaging (MRI).
LEVEL OF EVIDENCE
5 TECHNICAL EFFICACY: Stage 5 J. Magn. Reson. Imaging 2018;48:13-26.
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癌症仍是全球杀手，与心血管疾病并列。对癌症生物学的更好理解已经改变了其管理方式，越来越强调个性化方法，即所谓的“精准癌症医学”。影像学在癌症患者的管理中发挥着关键作用。影像学生物标志物可以客观地反映肿瘤生物学、肿瘤环境以及肿瘤对干预措施的变化，补充基因组和分子诊断。在这篇综述中，我们描述了影像学生物标志物开发的关键原则，并讨论了磁共振成像（MRI）的现状。
证据水平
5 技术功效：第 5 阶段 J. 磁共振成像 2018；48：13-26.
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