基于转录组学的化学毒性筛选和预测方法
Reduced Transcriptomic Approach for Screening and Prediction of Chemical Toxicity.
机构信息
Institute of Zoology , Chinese Academy of Sciences , Beijing 100101 , P. R. China.
出版信息
Chem Res Toxicol. 2018 Jul 16;31(7):532-533. doi: 10.1021/acs.chemrestox.8b00104. Epub 2018 Jul 3.
Abstract
The reduced transcriptomic approach allows full dose range testing of hundreds of chemicals or mixtures using human cells or zebrafish embryos. Points of departure of genes and pathways can be used for potency ranking and to classify chemicals by disrupted biological pathways.
摘要
采用简化的转录组学方法，能够使用人类细胞或斑马鱼胚胎对数百种化学品或混合物进行全剂量范围测试。基因和途径的起始点可用于效力排序，并根据破坏的生物途径对化学品进行分类。
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