Department of Medicine, University of Cambridge, Cambridge, UK.
Department of Medicine, University of Cambridge, Cambridge, UK.
J Hosp Infect. 2018 Sep;100(1):35-39. doi: 10.1016/j.jhin.2018.06.024. Epub 2018 Jun 30.
Infections with carbapenemase-producing Enterobacteriaceae (CPE) and vancomycin-resistant enterococci (VRE) are associated with increased morbidity and mortality, but the carriage rates of CRE and VRE among hospital inpatients are unknown. A point-prevalence survey was conducted to determine CPE and VRE carriage rates in hospitalized adults. Eight hundred and eighteen of 960 (85.2%) adult inpatients were invited to participate in the study. Of these, 595 patients (72.7%) consented and provided specimens. Of 540 samples tested, none were positive for CPE. One hundred and thirty of 540 (24.1%) samples were VRE positive, and 34 of 40 (85%) of wards had cases. Universal screening for CPE may not be cost-effective in low-prevalence settings, but targeted screening of high-risk patients should continue. The optimal screening strategy for VRE remains to be determined, as universal screening and isolation is not feasible in the study setting.
产碳青霉烯酶肠杆菌科（CPE）和耐万古霉素肠球菌（VRE）感染与发病率和死亡率增加有关，但住院患者中 CRE 和 VRE 的携带率尚不清楚。进行了一项时点患病率调查，以确定住院成年患者中 CPE 和 VRE 的携带率。818 名 960 名（85.2%）成年住院患者被邀请参加研究。其中，595 名患者（72.7%）同意并提供了标本。在 540 个测试样本中，没有一个对 CPE 呈阳性。在 540 个样本中，有 130 个（24.1%）样本为 VRE 阳性，40 个（85%）病房中有病例。在低流行地区，对 CPE 进行普遍筛查可能没有经济效益，但应继续对高危患者进行有针对性的筛查。VRE 的最佳筛查策略仍有待确定，因为在研究环境中不可能普遍筛查和隔离。
