小鼠中的细胞基因以反式作用调节内源性小鼠乳腺肿瘤病毒的表达。
Cellular genes in the mouse regulate in trans the expression of endogenous mouse mammary tumor viruses.
作者信息
Traina-Dorge V L, Carr J K, Bailey-Wilson J E, Elston R C, Taylor B A, Cohen J C
出版信息
Genetics. 1985 Nov;111(3):597-615. doi: 10.1093/genetics/111.3.597.
Abstract
The transcriptional activities of the eleven mouse mammary tumor virus (MMTV) proviruses endogenous to two sets of recombinant inbred (RI) mouse strains, BXD and BXH, were characterized. Comparison of the levels of virus-specific RNA quantitated in each strain showed no direct relationship between the presence of a particular endogenous provirus or with increasing numbers of proviruses. Association of specific genetic markers with the level of MMTV-specific RNA was examined by using multiple regression analysis. Several cellular loci as well as proviral loci were identified that were significantly associated with viral expression. Importantly, these cellular loci associated with MMTV expression segregated independently of viral sequences.
摘要
对两组重组近交（RI）小鼠品系BXD和BXH中内源性的11种小鼠乳腺肿瘤病毒（MMTV）前病毒的转录活性进行了表征。对每个品系中定量的病毒特异性RNA水平进行比较，结果显示特定内源性前病毒的存在或前病毒数量的增加之间没有直接关系。通过多元回归分析研究了特定遗传标记与MMTV特异性RNA水平的关联。确定了几个与病毒表达显著相关的细胞基因座以及前病毒基因座。重要的是，这些与MMTV表达相关的细胞基因座与病毒序列独立分离。
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