Zhang Yanli, Zhang Suiliang, Xia Wei, Dong Zhiyong
Department of Interventional Oncology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China.
Department of Gastrointestinal Surgery, The Affiliated Hospital of Putian University, Putian 351100, China.
J Cancer Res Ther. 2018 Jun;14(Supplement):S526-S532. doi: 10.4103/0973-1482.191065.
Results on the relationship between cytotoxic T-lymphocyte antigen 4 (CTLA4) +49A/G (rs231775) gene polymorphism and colorectal cancer risk are still debated. This meta-analysis was performed to assess the association between CTLA4 +49A/G and colorectal cancer risk.
The relevant studies were searched from PubMed, Cochrane Library, and China Biological Medicine Database-disc, and eligible investigations were included and synthesized using meta-analysis method.
Eleven studies were recruited into this meta-analysis for the association of CTLA4 A/G gene polymorphism and colorectal cancer risk, consisting of 1802 colorectal cancer patients and 2939 controls. G allele was a risk factor for the colorectal cancer risk, and AA genotype might be a protective factor against colorectal cancer risk in overall populations (G allele: Odds ratio [OR] = 1.19, 95% confidence interval [CI]: 1.03-1.38, P = 0.02; AA genotype: OR = 0.63, 95% CI: 0.47-0.84, P = 0.002). However, the GG genotype was not associated with colorectal cancer risk in overall populations.
The association between CTLA4 G allele/AA genotype and colorectal cancer risk was found in this meta-analysis.
细胞毒性T淋巴细胞相关抗原4（CTLA4）+49A/G（rs231775）基因多态性与结直肠癌风险之间关系的研究结果仍存在争议。本荟萃分析旨在评估CTLA4 +49A/G与结直肠癌风险之间的关联。
从PubMed、Cochrane图书馆和中国生物医学文献数据库中检索相关研究，并纳入符合条件的研究，采用荟萃分析方法进行综合分析。
本荟萃分析纳入了11项关于CTLA4 A/G基因多态性与结直肠癌风险关联的研究，共包括1802例结直肠癌患者和2939例对照。G等位基因是结直肠癌风险的一个危险因素，而AA基因型可能是总体人群中结直肠癌风险的一个保护因素（G等位基因：比值比[OR]=1.19，95%置信区间[CI]：1.03-1.38，P=0.02；AA基因型：OR=0.63，95%CI：0.47-0.84，P=0.002）。然而，GG基因型与总体人群的结直肠癌风险无关。
本荟萃分析发现CTLA4 G等位基因/AA基因型与结直肠癌风险之间存在关联。
