Neoplasma. 2017;64(2):299-304. doi: 10.4149/neo_2017_218.
Systematic reviews on osteosarcoma have concluded that CTLA4 rs231775 AA genotype influences risk for the disease in the Chinese population. Remarkably, rs231775 shows different frequencies in different human populations. Therefore, it would be interesting to know whether this SNP is related to the risk of osteosarcoma in other populations. The present study aimed to evaluate the association between rs231775 and the susceptibility of osteosarcoma in the Spanish population. We performed an updated meta-analysis including a total of 538 cases and 623 controls. The genotypic association analyses showed that the CTLA4 rs231755 was associated with osteosarcoma susceptibility in the Spanish population. When meta-analysis was performed, the results displayed that CTLA4 rs231775 AA genotype was associated with the risk of developing osteosarcoma in all analyzed populations (OR=2.07; 95% CI: 1.48-2.89).The rs231775 AA genotype could be considered as a susceptibility marker in osteosarcoma Keywords: CTLA4, rs231775, +49A/G and osteogenic sarcoma.
系统综述骨肉瘤的结论认为 CTLA4 rs231775 AA 基因型影响中国人群的疾病风险。值得注意的是，rs231775 在不同人群中的频率不同。因此，了解这个 SNP 是否与其他人群的骨肉瘤风险有关将是很有趣的。本研究旨在评估 rs231775 与西班牙人群骨肉瘤易感性之间的关系。我们进行了一项更新的荟萃分析，共纳入了 538 例病例和 623 例对照。基因型关联分析表明，CTLA4 rs231755 与西班牙人群骨肉瘤易感性相关。当进行荟萃分析时，结果显示 CTLA4 rs231775 AA 基因型与所有分析人群中骨肉瘤的发病风险相关（OR=2.07；95%CI：1.48-2.89）。rs231775 AA 基因型可被视为骨肉瘤的易感标志物。关键词：CTLA4，rs231775，+49A/G 和骨肉瘤。
