Isaacs Mark A, Barbero Brunella, Durndell Lee J, Hilton Anthony C, Olivi Luca, Parlett Christopher M A, Wilson Karen, Lee Adam F
Department of Chemistry, University College London, London WC1H 0AJ, UK.
European Bioenergy Research Institute, Aston University, Birmingham B4 7ET, UK.
Antibiotics (Basel). 2018 Jul 3;7(3):55. doi: 10.3390/antibiotics7030055.
Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure-function relationships. A family of chemically and structurally modified mesoporous SBA-15 silicas were synthesized as porous host matrices to tune the physicochemical properties of silver nanoparticles. Physicochemical characterization by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and porosimetry demonstrate that functionalization by a titania monolayer and the incorporation of macroporosity both increase silver nanoparticle dispersion throughout the silica matrix, thereby promoting Ag₂CO₃ formation and the release of ionic silver in simulated tissue fluid. The Ag₂CO₃ concentration within functionalized porous architectures is a strong predictor for antibacterial efficacy against a broad spectrum of pathogens, including and methicillin-resistant Staphylococcus aureus (MRSA).
医疗保健相关感染以及耐药细菌的出现对现有的抗生素疗法构成了重大挑战。银纳米复合材料是应对当前危机的一个有前景的解决方案，然而其治疗应用需要对基础的结构 - 功能关系有更深入的了解。合成了一系列化学和结构改性的介孔SBA - 15二氧化硅作为多孔主体基质，以调节银纳米颗粒的物理化学性质。通过透射电子显微镜（TEM）、X射线衍射（XRD）、X射线光电子能谱（XPS）、X射线吸收近边光谱（XANES）和孔隙率测定法进行的物理化学表征表明，二氧化钛单层功能化和大孔隙的引入都增加了银纳米颗粒在整个二氧化硅基质中的分散性，从而促进了Ag₂CO₃的形成以及离子银在模拟组织液中的释放。功能化多孔结构内的Ag₂CO₃浓度是对包括耐甲氧西林金黄色葡萄球菌（MRSA）在内的多种病原体抗菌效力的有力预测指标。
