Kristianstad Central Hospital, SE-29185 Kristianstad, Sweden.
School of Health & Society, Kristianstad University, SE-29188 Kristianstad, Sweden.
Int J Mol Sci. 2018 Jul 3;19(7):1949. doi: 10.3390/ijms19071949.
Periodontal disease, periodontitis as well as the preceding gingivitis, has been associated with both obesity and diabetes. Studies have shown that diet changes can lead to a lower incidence of such inflammation. The aim of the present case series over four weeks was to study the effects on medical and dental conditions in patients with type 2 diabetes of the consumption of the Okinawan-based Nordic Diet (OBND). Medical and dental examinations were performed to estimate the general health and gingivitis/periodontitis. Serum cytokine levels were assessed using Luminex technology. Eight of ten study participants completed the study. All participants lost weight ( = 0.012). Six out of seven that were treated with insulin could reduce their insulin intake after two weeks with OBND. The reduction was about 16 units which corresponds to a 34% relative reduction compared to the starting point (range 15–63%). Fasting blood glucose values fell ( = 0.035). Hemoglobin A1c (HbA1c) ( = 0.01), triglycerides ( = 0.05), and low-density lipoprotein (LDL) ( = 0.05) were also reduced. Bleeding on probing changed from ~28% before any dietary changes to ~13% after two weeks with OBND ( = 0.01). The reduction in gingival bleeding was as substantial as might be expected from one session of professional tooth cleaning. Markers of inflammation were also reduced. The OBND thus showed significant promise in alleviating the impact of diabetes on dental as well as general health.
牙周病、牙周炎以及之前的牙龈炎，与肥胖和糖尿病都有关系。研究表明，饮食的改变可能会降低此类炎症的发生率。本为期四周的病例系列研究旨在研究冲绳北欧饮食（OBND）对 2 型糖尿病患者的医疗和牙科状况的影响。进行了医学和牙科检查，以评估患者的整体健康状况和牙龈炎/牙周炎状况。使用 Luminex 技术评估血清细胞因子水平。十名研究参与者中有八名完成了研究。所有参与者都减轻了体重（ = 0.012）。接受胰岛素治疗的七名参与者中有六名可以在接受 OBND 治疗两周后减少胰岛素的摄入量。减少量约为 16 个单位，与起点相比相对减少了 34%（范围 15-63%）。空腹血糖值下降（ = 0.035）。血红蛋白 A1c（HbA1c）（ = 0.01）、甘油三酯（ = 0.05）和低密度脂蛋白（LDL）（ = 0.05）也有所降低。在接受任何饮食改变之前，探诊出血率约为 28%，而在接受 OBND 治疗两周后，探诊出血率约为 13%（ = 0.01）。牙龈出血的减少量与一次专业洁牙所预期的减少量相当。炎症标志物也有所降低。因此，冲绳北欧饮食在减轻糖尿病对牙科和整体健康的影响方面显示出了很大的希望。
