Casas Rosa, Urpi-Sardà Mireia, Sacanella Emilio, Arranz Sara, Corella Dolores, Castañer Olga, Lamuela-Raventós Rosa-María, Salas-Salvadó Jordi, Lapetra José, Portillo Maria P, Estruch Ramón
Department of Internal Medicine, Hospital Clinic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036 Barcelona, Spain.
Ciber Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
Mediators Inflamm. 2017;2017:3674390. doi: 10.1155/2017/3674390. Epub 2017 Apr 18.
To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. . 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1 ( < 0.05; all) compared to LFD. IL-1, IL-5, IL-7, IL-12p70, IL-18, TNF-, IFN-, GCSF, GMCSF, and ENA78 ( < 0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 ( < 0.05; both) in the MeDiet+nuts group. . Long-term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.
为评估地中海饮食（MeDiet）干预对心血管疾病高危老年人血浆中炎症及斑块稳定性相关分子浓度的长期影响。来自巴塞罗那医院诊所附属基层医疗中心的66名参与者被随机分为3组：地中海饮食加特级初榨橄榄油（EVOO）组、地中海饮食加坚果组和低脂饮食（LFD）组。在基线、3年和5年时，我们通过Luminex®评估了24种与动脉粥样硬化进程不同阶段相关的炎症生物标志物的血浆浓度变化。在3年和5年时，与低脂饮食组相比，两个地中海饮食组的白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、单核细胞趋化蛋白-1（MCP-1）和巨噬细胞炎性蛋白-1（MIP-1）均显著降低（均P<0.05）。白细胞介素-1（IL-1）、白细胞介素-5（IL-5）、白细胞介素-7（IL-7）、白细胞介素-12p70、白细胞介素-18、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）、粒细胞集落刺激因子（GCSF）、粒细胞-巨噬细胞集落刺激因子（GMCSF）和ENA78（均P<0.05）仅在MeDiet+EVOO组中降低，而E-选择素和可溶性血管细胞黏附分子-1（sVCAM-1）（均P<0.05）仅在MeDiet+坚果组中降低。长期坚持地中海饮食可降低心血管疾病高危老年人血浆中与动脉粥样斑块发展不同阶段相关的炎症生物标志物浓度。
