Mougias Antonios A, Christidi Foteini, Kontogianni Evaggelia, Skaltsounaki Elena, Politis Anastasios, Politis Antonios
Alzheimer Center, Greek Psychogeriatric Association "Nestor", Athens, Greece.
Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Curr Gerontol Geriatr Res. 2018 Jun 4;2018:9396160. doi: 10.1155/2018/9396160. eCollection 2018.
Informant-based rating scales are widely used in dementia but patients' and caregivers' features influence the final scoring. We aimed to evaluate the role of patient- and caregiver-related factors in a caregiver rated Global Deterioration Scale (GDS) score in a sample of Greek patients with dementia.
We included 194 patients with dementia and 194 caregivers/family relatives; Mini-Mental State Examination (MMSE); Neuropsychiatric Inventory (NPI); Katz Index of Activities of Daily Living (K-IADL) were administered to (a) patients and Center for Epidemiologic Studies-Depression (CES-D) Scale; Zarit Burden Interview (ZBI) to (b) caregivers. Participants' demographics and patients' and caregivers' characteristics were entered into a 3-block regression analysis.
The final model explained 55% of the total variance of the caregiver assessed GDS score. The following variables significantly contributed to the final model: MMSE (=-0.524); K-IADL (-0.264); ZBI (=0.145).
We herein confirm the contribution of patients' cognitive and functional status and caregivers' burden in caregiver rated GDS scoring irrespective of demographic-related characteristics.
基于 informant 的评定量表在痴呆症中广泛使用，但患者和照料者的特征会影响最终评分。我们旨在评估希腊痴呆症患者样本中与患者和照料者相关因素在照料者评定的总体衰退量表（GDS）评分中的作用。
我们纳入了 194 名痴呆症患者和 194 名照料者/家属；对（a）患者进行简易精神状态检查表（MMSE）、神经精神科问卷（NPI）、日常生活活动能力 Katz 指数（K-IADL）以及流行病学研究中心抑郁量表（CES-D）；对（b）照料者进行 Zarit 负担访谈（ZBI）。将参与者的人口统计学数据以及患者和照料者的特征纳入三阶段回归分析。
最终模型解释了照料者评定的 GDS 评分总方差的 55%。以下变量对最终模型有显著贡献：MMSE（=-0.524）；K-IADL（-0.264）；ZBI（=0.145）。
我们在此证实了患者的认知和功能状态以及照料者的负担在照料者评定的 GDS 评分中的作用，而与人口统计学相关特征无关。
