Park Sehoon, Lee Soojin, Jo Hyung Ah, Han Kyungdo, Kim Yaerim, An Jung Nam, Joo Kwon Wook, Lim Chun Soo, Kim Yon Su, Kim Hyeongsu, Kim Dong Ki
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Kidney Res Clin Pract. 2018 Jun;37(2):119-129. doi: 10.23876/j.krcp.2018.37.2.119. Epub 2018 Jun 30.
Continuous renal replacement therapy (CRRT) is an important treatment modality for severe acute kidney injury. As such, the epidemiology of CRRT in Korea needs further investigation.
We conducted a nationwide, population-based study analyzing the claims data from National Health Insurance Service of Korea. All index intensive care unit admission cases of CRRT in government-designated tertiary referral hospitals in Korea from 2005 to 2016 were included. Patients with a history of renal replacement therapy or who were under 20 years old were not considered. In addition to baseline and treatment characteristics, patient outcomes, including all-cause mortality and renal survival rates, were investigated. We stratified the study patients according to 3-year time periods and major regions of the nation.
We included 37,337 patients who received CRRT in Korea. The overall use of CRRT increased over time, and more than 80% of cases of acute renal replacement therapy were CRRT after 2014. Seoul was the region in which the majority of CRRT (45.0%) was performed. The clinical characteristics of CRRT patients were significantly different among time-intervals and regions. Both all-cause mortality and renal survival rates after CRRT were prominently improved in the recent time periods ( < 0.001).
CRRT is a widely used treatment strategy for severe acute kidney injury in Korea. The prognosis of CRRT patients has improved compared to the past. This epidemiological study of CRRT in Korea revealed notable trends with regard to time period and geographic region.
连续性肾脏替代治疗（CRRT）是治疗严重急性肾损伤的重要方式。因此，韩国CRRT的流行病学情况需要进一步研究。
我们开展了一项基于全国人口的研究，分析了韩国国民健康保险服务的理赔数据。纳入了2005年至2016年韩国政府指定的三级转诊医院中所有首次入住重症监护病房并接受CRRT治疗的病例。有肾脏替代治疗史或年龄在20岁以下的患者被排除。除了基线和治疗特征外，还调查了患者的预后情况，包括全因死亡率和肾脏存活率。我们根据3年时间段和国家主要地区对研究患者进行了分层。
我们纳入了韩国37337例接受CRRT治疗的患者。CRRT的总体使用量随时间增加，2014年后超过80%的急性肾脏替代治疗病例为CRRT。首尔是进行CRRT治疗病例最多的地区（45.0%）。CRRT患者的临床特征在不同时间段和地区之间存在显著差异。在最近时间段，CRRT后的全因死亡率和肾脏存活率均有显著改善（<0.001）。
CRRT是韩国治疗严重急性肾损伤广泛使用的治疗策略。与过去相比，CRRT患者的预后有所改善。这项韩国CRRT的流行病学研究揭示了在时间段和地理区域方面的显著趋势。
