Laboratoire Biochimie et Toxicologie des Substances Bioactives (EA BTSB 7417), University of Toulouse, INU Champollion, Albi, France.
EPOC UMR 5805, University of Bordeaux, Pessac, France.
Environ Sci Pollut Res Int. 2018 Sep;25(26):26090-26102. doi: 10.1007/s11356-018-2501-5. Epub 2018 Jul 3.
The primary source of pharmaceuticals to the aquatic environment is the discharge of wastewater effluents. Pharmaceuticals are a large and diverse group of compounds. Among them, psychotropic substances are particularly interesting to study due to their specific known mode of action. The present study was performed to investigate the effects of wastewater effluents from a psychiatric hospital wastewater treatment plant (WWTP) on several aquatic organisms. All the analyzed pharmaceuticals (10 compounds) were detected in WWTP effluents as well as in the receiving river. Although the environmental concentrations were generally at trace levels (ng L to μg L), induce toxic effects were observed. This study showed the effects of the WWTP effluents on the oogenesis and/or embryogenesis of amphipod crustacean Gammarus fossarum, Japanese fish medaka Oryzias latipes, mollusk Radix peregra, and planarian Schmidtea polychroa. A decrease of the number of oocytes and produced embryos was observed for G. fossarum and S. polychroa. Similarly, the hatching rate of R. peregra was affected by effluents. In the receiving river, the macroinvertebrate community was affected by the wastewater effluents discharge.
药品进入水生态环境的主要源头是废水排放。药品是一大类具有多种特性的化合物。其中，精神药物因其特定的已知作用模式而特别值得研究。本研究旨在调查精神病院废水处理厂（WWTP）的废水对几种水生生物的影响。所有分析的药品（10 种化合物）均在 WWTP 废水中以及在受纳河流中被检出。尽管环境浓度通常处于痕量水平（ng/L 至 μg/L），但仍观察到了有毒效应。本研究表明 WWTP 废水对水生无脊椎动物淡水长臂虾的卵子发生和/或胚胎发生、日本青鳉鱼、圆田螺和多毛虫的影响。观察到淡水长臂虾和多毛虫的卵母细胞数量和产生的胚胎数量减少。同样，废水对圆田螺的孵化率有影响。在受纳河流中，污水排放影响了大型底栖无脊椎动物群落。
