Peng Jia-Yu, Huang Ying, Ou Jiang-Yan, Yang Yang
Respiratory Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2018 Jun;20(6):456-460. doi: 10.7499/j.issn.1008-8830.2018.06.005.
To study the association of blood lipids with the development, clinical stage, allergic condition, and pulmonary function of asthma.
A total of 56 children with asthma who attended the hospital between October 2016 and March 2017 were enrolled as the asthma group, and 46 children who underwent physical examination as the healthy control group. According to the clinical manifestations, the children with asthma were divided into acute exacerbation group (n=24) and chronic persistent group (n=32). According to the results of skin prick test (SPT) and serum IgE measurement, the children with asthma were divided into non-allergic asthma group (n=16) and allergic asthma group (n=38). Fasting blood lipid levels were measured in both asthma and control groups. Pulmonary function tests were performed for asthmatic children.
There were no significant differences in blood lipid levels between the asthma and control groups (P>0.05). The acute exacerbation group had significantly lower serum levels of high-density lipoprotein (HDL) and total cholesterol compared with the control group and the chronic persistent group (P<0.05). The allergic asthma group had a significantly lower serum HDL level than the non-allergic asthma group (P<0.05). In asthmatic children aged 6-13 years, the ratios of the measured values to the predicted values for forced vital capacity, peak expiratory flow, and maximal expiratory flow at 50% of vital capacity had a linear regression relationship with HDL and were positively correlated with HDL (P<0.05). Forced expiratory volume in one second and maximal mid-expiratory flow had a linear regression relationship with both HDL and LDL and were positively correlated with them (P<0.05).
Blood lipids are associated with the clinical stage, allergic condition, and lung function of childhood asthma. This indicates that blood lipids may be involved in several aspects of the pathogenesis of childhood asthma.
研究血脂与哮喘的发生发展、临床分期、过敏状况及肺功能的关系。
选取2016年10月至2017年3月期间在我院就诊的56例哮喘患儿作为哮喘组，46例体检儿童作为健康对照组。根据临床表现，将哮喘患儿分为急性加重组（n = 24）和慢性持续组（n = 32）。根据皮肤点刺试验（SPT）和血清IgE检测结果，将哮喘患儿分为非过敏性哮喘组（n = 16）和过敏性哮喘组（n = 38）。检测哮喘组和对照组的空腹血脂水平。对哮喘患儿进行肺功能检查。
哮喘组与对照组血脂水平差异无统计学意义（P > 0.05）。急性加重组血清高密度脂蛋白（HDL）和总胆固醇水平显著低于对照组和慢性持续组（P < 0.05）。过敏性哮喘组血清HDL水平显著低于非过敏性哮喘组（P < 0.05）。在6 - 13岁哮喘患儿中，用力肺活量、呼气峰值流速和肺活量50%时的最大呼气流量实测值与预测值的比值与HDL呈线性回归关系，且与HDL呈正相关（P < 0.05）。一秒用力呼气容积和最大呼气中期流速与HDL和低密度脂蛋白（LDL）均呈线性回归关系，且与它们呈正相关（P < 0.05）。
血脂与儿童哮喘的临床分期、过敏状况及肺功能有关。这表明血脂可能参与儿童哮喘发病机制的多个方面。
