血清载脂蛋白A-I和大型高密度脂蛋白颗粒与特应性哮喘患者的第一秒用力呼气容积呈正相关。
Serum apolipoprotein A-I and large high-density lipoprotein particles are positively correlated with FEV1 in atopic asthma.
作者信息
Barochia Amisha V, Kaler Maryann, Cuento Rosemarie A, Gordon Elizabeth M, Weir Nargues A, Sampson Maureen, Fontana Joseph R, MacDonald Sandra, Moss Joel, Manganiello Vincent, Remaley Alan T, Levine Stewart J
机构信息
1 Laboratory of Asthma and Lung Inflammation, NHLBI.
出版信息
Am J Respir Crit Care Med. 2015 May 1;191(9):990-1000. doi: 10.1164/rccm.201411-1990OC.
RATIONALE
Although lipids, apolipoproteins, and lipoprotein particles are important modulators of inflammation, varying relationships exist between these parameters and asthma.
OBJECTIVES
To determine whether serum lipids and apolipoproteins correlate with the severity of airflow obstruction in subjects with atopy and asthma.
METHODS
Serum samples were obtained from 154 atopic and nonatopic subjects without asthma, and 159 subjects with atopy and asthma. Serum lipid and lipoprotein levels were quantified using standard diagnostic assays and nuclear magnetic resonance (NMR) spectroscopy. Airflow obstruction was assessed by FEV1% predicted.
MEASUREMENTS AND MAIN RESULTS
Serum lipid levels correlated with FEV1 only in the subjects with atopy and asthma. Serum levels of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) were positively correlated with FEV1 in subjects with atopy and asthma, whereas a negative correlation existed between FEV1 and serum levels of triglycerides, low-density lipoprotein (LDL) cholesterol, apolipoprotein B (apoB), and the apoB/apoA-I ratio. NMR spectroscopy identified a positive correlation between FEV1 and HDLNMR particle size, as well as the concentrations of large HDLNMR particles and total IDLNMR (intermediate-density lipoprotein) particles in subjects with atopy and asthma. In contrast, LDLNMR particle size and concentrations of LDLNMR and VLDLNMR (very-low-density lipoprotein) particles were negatively correlated with FEV1 in subjects with atopy and asthma.
CONCLUSIONS
In subjects with atopy and asthma, serum levels of apoA-I and large HDLNMR particles are positively correlated with FEV1, whereas serum triglycerides, LDL cholesterol, and apoB are associated with more severe airflow obstruction. These results may facilitate future studies to assess whether apoA-I and large HDLNMR particles can reduce airflow obstruction and disease severity in asthma.
原理
尽管脂质、载脂蛋白和脂蛋白颗粒是炎症的重要调节因子，但这些参数与哮喘之间存在不同的关系。
目的
确定血清脂质和载脂蛋白是否与特应性和哮喘患者的气流阻塞严重程度相关。
方法
从154名无哮喘的特应性和非特应性受试者以及159名特应性和哮喘患者中获取血清样本。使用标准诊断测定法和核磁共振（NMR）光谱法定量血清脂质和脂蛋白水平。通过预测的FEV1评估气流阻塞情况。
测量结果与主要结果
仅在特应性和哮喘患者中，血清脂质水平与FEV1相关。在特应性和哮喘患者中，高密度脂蛋白（HDL）胆固醇和载脂蛋白A-I（apoA-I）的血清水平与FEV1呈正相关，而FEV1与甘油三酯、低密度脂蛋白（LDL）胆固醇、载脂蛋白B（apoB）以及apoB/apoA-I比值的血清水平呈负相关。NMR光谱法确定，在特应性和哮喘患者中，FEV1与HDLNMR颗粒大小以及大HDLNMR颗粒和总IDLNMR（中密度脂蛋白）颗粒的浓度呈正相关。相比之下，在特应性和哮喘患者中，LDLNMR颗粒大小以及LDLNMR和VLDLNMR（极低密度脂蛋白）颗粒的浓度与FEV1呈负相关。
结论
在特应性和哮喘患者中，apoA-I和大HDLNMR颗粒的血清水平与FEV1呈正相关，而血清甘油三酯、LDL胆固醇和apoB与更严重的气流阻塞相关。这些结果可能有助于未来的研究，以评估apoA-I和大HDLNMR颗粒是否可以减轻哮喘中的气流阻塞和疾病严重程度。
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