Department of Science Education/Creative Convergent Manufacturing Engineering, Dankook University, Yongin 448-701, Korea.
Nanoscale. 2018 Jul 19;10(28):13502-13510. doi: 10.1039/c8nr02192a.
In this study, a combined system of microneedles and a triboelectric nanogenerator (TENG) has been developed for drug delivery. A triboelectric device, which converts mechanical energy into alternating current (AC), was chosen to replace the electrophoresis (EP) effect. To directly generate triboelectricity from salmon deoxyribonucleic acid (SDNA)-based microneedles, a triboelectric series of SDNA film and chargeable polymers (polyimide and Teflon) was studied. The electrical output of the two charged polymers was compared to find a material that could be highly charged with SDNA. The electrical output was also compared as a function of the concentration of a drug embedded in the SDNA film, and the results confirmed that drug intercalation affected the carrier diffusion. The mechanical strength of the microneedles was assessed by histological analysis of their penetration into porcine cadaver skin. Furthermore, the output voltage of a system incorporating microneedles and TENG in cadaver skin, and in vitro drug release into gelatin were evaluated to examine potential application as an electrically active drug delivery system. The electrical output voltage of this system was ∼95 V. The mechanism of triboelectric perturbation to the skin has also been discussed. The system developed in this work is a new, facile approach toward effective drug delivery that replaces the existing EP method and expands the application of TENGs.
在这项研究中，开发了一种基于微针和摩擦纳米发电机（TENG）的组合系统用于药物输送。选择摩擦发电装置（将机械能转换为交流电（AC））来替代电泳（EP）效应。为了直接从基于鲑鱼脱氧核糖核酸（SDNA）的微针产生摩擦电，研究了 SDNA 薄膜和可充电聚合物（聚酰亚胺和特氟龙）的摩擦电序列。比较了两种带电荷聚合物的电输出，以找到一种可以与 SDNA 高度带电的材料。还比较了药物嵌入 SDNA 薄膜的浓度对电输出的影响，结果证实药物嵌入会影响载体扩散。通过对微针穿透猪尸体皮肤的组织学分析评估了微针的机械强度。此外，还评估了在尸体皮肤和明胶中的体外药物释放中结合微针和 TENG 的系统的输出电压，以检查作为电活性药物输送系统的潜在应用。该系统的输出电压约为 95 V。还讨论了摩擦电对皮肤的扰动机制。本工作中开发的系统是一种新的简便方法，用于有效药物输送，取代了现有的 EP 方法，并扩展了 TENG 的应用。
