Han Jieun, Choi Yi-Jeong, Kang Seung-Kyun
Department of Materials Science and Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
Interdisciplinary Program of Bioengineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, South Korea.
Adv Healthc Mater. 2024 Dec;13(30):e2401753. doi: 10.1002/adhm.202401753. Epub 2024 Aug 1.
Transdermal healthcare systems have gained significant attention for their painless and convenient drug administration, as well as their ability to detect biomarkers promptly. However, the skin barrier limits the candidates of biomolecules that can be transported, and reliance on simple diffusion poses a bottleneck for personalized diagnosis and treatment. Consequently, recent advancements in transdermal transport technologies have evolved toward active methods based on external energy sources. Multiple combinations of these technologies have also shown promise for increasing therapeutic effectiveness and diagnostic accuracy as delivery efficiency is maximized. Furthermore, wearable healthcare platforms are being developed in diverse aspects for patient convenience, safety, and on-demand treatment. Herein, a comprehensive overview of active transdermal delivery technologies is provided, highlighting the combination-based diagnostics, therapeutics, and theragnostics, along with the latest trends in platform advancements. This offers insights into the potential applications of next-generation wearable transdermal medical devices for personalized autonomous healthcare.
经皮医疗系统因其无痛、便捷的药物给药方式以及快速检测生物标志物的能力而备受关注。然而，皮肤屏障限制了可运输生物分子的种类，且依赖简单扩散对个性化诊断和治疗构成了瓶颈。因此，经皮运输技术的最新进展已朝着基于外部能源的主动方法发展。这些技术的多种组合在提高治疗效果和诊断准确性方面也显示出前景，因为递送效率得到了最大化。此外，为了方便患者、保障安全并实现按需治疗，正在从多个方面开发可穿戴医疗平台。在此，提供了主动经皮递送技术的全面概述，重点介绍了基于组合的诊断、治疗和诊疗方法，以及平台进展的最新趋势。这为下一代可穿戴经皮医疗设备在个性化自主医疗中的潜在应用提供了见解。
