基于抗菌金纳米颗粒的万古霉素耐药菌光热杀伤作用。
Antibacterial gold nanoparticle-based photothermal killing of vancomycin-resistant bacteria.
机构信息
Department of Applied Chemistry, National Chiao Tung University, Hsinchu 300, Taiwan.
出版信息
Nanomedicine (Lond). 2018 Jun;13(12):1405-1416. doi: 10.2217/nnm-2017-0380. Epub 2018 Jul 4.
AIM
The extensive use of vancomycin has given rise to vancomycin-resistant bacterial strains, such as vancomycin-resistant Enterococci (VRE). We aim to explore potent medical treatments that can inhibit the growth of VRE.
MATERIALS & METHODS: Vancomycin-immobilized gold nanoparticles (Au@Van NPs) with polygonal shapes from one-pot reactions were generated within approximately 7 min.
RESULTS & DISCUSSION: The as-prepared Au NPs exhibit not only antibacterial capability but also photothermal competence. The temperature of the sample solution containing the as-prepared Au@Van NPs can be raised by approximately 15°C under irradiation by a near-infrared laser (λ = 808 nm) within 5 min.
CONCLUSION
The required amount of vancomycin on the as-prepared Au@Van NPs combined with near-infrared irradiation for inhibiting VRE is approximately 16-fold lower than that of free-form vancomycin.
目的
万古霉素的广泛使用导致了耐万古霉素的细菌株，如耐万古霉素肠球菌（VRE）。我们旨在探索能够抑制 VRE 生长的有效医学治疗方法。
材料与方法
采用一锅法在 7 分钟内生成具有多边形的万古霉素固定化金纳米粒子（Au@Van NPs）。
结果与讨论
所制备的 Au NPs 不仅具有抗菌能力，还具有光热能力。在近红外激光（λ=808nm）照射下，含有所制备的 Au@Van NPs 的样品溶液的温度在 5 分钟内可升高约 15°C。
结论
与游离形式的万古霉素相比，用于抑制 VRE 的所制备的 Au@Van NPs 上所需的万古霉素量减少了约 16 倍，同时结合近红外辐射。
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