Li L, Yu H T, Wang X D, Zhou F, Wang F, Wang C F
Department of Oral and Craniomaxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology & National Clinical Research Center of Stomatology, Shanghai 200011, China.
Department of Health Information, Shanghai Municipal Central for Disease Control and Prevention, Shanghai 200336, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 May 9;53(5):301-306. doi: 10.3760/cma.j.issn.1002-0098.2018.05.003.
To analysis the rate of birth defects of cleft lip and palate among newborns in Shanghai during 2007 and 2016 and describe its change trend, for the purpose of prevention, treatment and nursing of newborns with cleft lip and palate. Birth registration information in Shanghai during January 2007 and December 2016 were collected. Rate of birth defects, gender ratio and maternal age of newborns with cleft lip and palate were analyzed. Annual percent change was applied to analyze the trend. The total birth defect rate of children with cleft lip and palate was 937/million in the past 10 years in Shanghai, showing an overall decreasing trend, decreased 28.20% compared to the data of 2007. The total birth defect rate of newborns with cleft lip decreased 40.86%. Overall decline rate of newborns with cleft lip and palate was 54.60%, but birth defect rate of newborns with the isolated cleft palate rised 14.34%. The number of female isolated cleft palate newborns were 1.6 times higher than those of male isolated cleft palate newborns, male newborns with cleft lip were 1.8 times higher than that of the female newborns with cleft lip. Male newborns with cleft lip and palate were 1.5 times as much as the female newborns with cleft lip and palate. Maternal age is mainly 25 to 29 years old, accounting for 42.01% of the total number of mothers, the according birth defect rate was lowest as 853/million. When maternal age is too low or too high, the risk of neonatal cleft lip and palate could increase. Birth defects of cleft lip and palate was up to 130.8/million when maternal age is less than 20, while birth defects of cleft lip and palate was up to 188.2/million when maternal age over 40 years old. In recent 10 years, the overall rate of birth defects of cleft lip and palate in Shanghai shows a decreasing trend, with cleft lip and palate declining obviously, but isolate cleft palate has an increasing tendency. Maternal age less than 20 years old or more than 40 years old will increase the risk of birth defects in newborns with cleft lip and palate.
分析2007年至2016年上海新生儿唇腭裂出生缺陷发生率并描述其变化趋势，以便对唇腭裂新生儿进行预防、治疗及护理。收集2007年1月至2016年12月上海的出生登记信息。分析唇腭裂新生儿的出生缺陷率、性别比及母亲年龄。采用年变化率分析趋势。过去10年上海唇腭裂患儿的总出生缺陷率为937/百万，呈总体下降趋势，与2007年数据相比下降了28.20%。唇裂新生儿的总出生缺陷率下降了40.86%。唇腭裂新生儿的总体下降率为54.60%，但单纯腭裂新生儿的出生缺陷率上升了14.34%。单纯腭裂女新生儿数量是男新生儿的1.6倍，唇裂男新生儿数量是女新生儿的1.8倍。唇腭裂男新生儿数量是女新生儿的1.5倍。母亲年龄主要在25至29岁，占母亲总数的42.01%，相应的出生缺陷率最低，为853/百万。当母亲年龄过低或过高时，新生儿唇腭裂风险可能增加。母亲年龄小于20岁时唇腭裂出生缺陷率高达130.8/百万，而母亲年龄超过40岁时唇腭裂出生缺陷率高达188.2/百万。近10年上海唇腭裂出生缺陷总体发生率呈下降趋势，唇裂和腭裂下降明显，但单纯腭裂有上升倾向。母亲年龄小于20岁或大于40岁会增加新生儿唇腭裂出生缺陷风险。
