Wu Wenli, Sun Jing, Liu Huiyan, Chen Biting, Gao Zijun, Chen Yiyang, Li Fan, Wang Hongtao
Department of Oral and Maxillofacial Surgery, Stomatology Medical Center, Guangzhou Women and Children's Medical Center, Guangzhou, China.
Department of Clinical Nutrition, Guangzhou Women and Children's Medical Center, Guangzhou, China.
Front Pediatr. 2020 Apr 21;8:194. doi: 10.3389/fped.2020.00194. eCollection 2020.
Malnutrition is a characteristic feature of cleft lip with or without palate (CL/P). This study aims to retrospectively quantify the physical growth status, evaluate the feeding methods, and identify the possible correlation of CL/P types with growth failure. The length and weight of 508 infants with CL/P and 118 healthy infants were recorded at the date of admission. The weight-for-age (W/A), length-for-age (L/A), and body mass index-for-age (BMI) of the infants were calculated. The L/A values were significantly lower in the infants with cleft lip (CL, 123 cases) and cleft lip with palate (CLP, 122 cases) than those of the control infants ( < 0.01). The W/A values of the infants with CP (263 cases) and CLP were significantly lower than those of the control infants ( < 0.05). However, the BMI index was not significantly different between any of the studied groups and the controls. In the mixed feeding group, the infants with CL and CP showed significantly lower L/A ( < 0.05) and W/A ( < 0.05), respectively. Physical growth issues were more common in the infants with CP and CLP. Because this was a retrospective study, the foods supplied to the patients were not strictly uniform, therefore, a prospective study with unified food supplement may be needed to confirm these findings.
营养不良是唇腭裂（CL/P）的一个典型特征。本研究旨在回顾性地量化身体生长状况，评估喂养方式，并确定CL/P类型与生长发育迟缓之间可能存在的相关性。记录了508例唇腭裂婴儿和118例健康婴儿入院时的身长和体重。计算了这些婴儿的年龄别体重（W/A）、年龄别身长（L/A）和年龄别体重指数（BMI）。唇裂（CL，123例）和腭裂（CLP，122例）婴儿的L/A值显著低于对照组婴儿（<0.01）。腭裂（CP，263例）和CLP婴儿的W/A值显著低于对照组婴儿（<0.05）。然而，任何研究组与对照组之间的BMI指数均无显著差异。在混合喂养组中，CL和CP婴儿的L/A（<0.05）和W/A（<0.05）分别显著较低。CP和CLP婴儿的身体生长问题更为常见。由于这是一项回顾性研究，提供给患者的食物并不严格统一，因此，可能需要进行一项采用统一食物补充的前瞻性研究来证实这些发现。
