迟发性皮肤卟啉症与肝细胞癌。发生率及相关因素。

Porphyria cutanea tarda and hepatocellular carcinoma. Frequency of occurrence and related factors.

作者信息

Salata H, Cortés J M, Enríquez de Salamanca R, Oliva H, Castro A, Kusak E, Carreño V, Hernandez Guío C

出版信息

J Hepatol. 1985;1(5):477-87. doi: 10.1016/s0168-8278(85)80746-7.

Abstract

In order to assess the incidence of hepatocellular carcinoma (HCC) in porphyria cutanea tarda (PCT), 83 patients (77 males, 6 females, mean age 57.4 years) were studied. Thirteen patients (15.7%) had HCC, all of whom were male and cirrhotics with a mean age of 58.5 years. HCC patients showed a statistically significant (P less than 0.0005) longer evolution time (23 years since onset of the cutaneous disease) than patients without HCC (9.4 years), while the age of onset was similar in both groups. Differences in alcohol intake and hepatitis B virus (HBV) markers were non-significant, although high prevalence (54%) of past HBV infection was found in both groups. In HCC development, attributable risks of 100% were found for cirrhosis (P less than 0.001), male sex (P = NS) and for age over 51 (P less than 0.025). Therefore, PCT harbours a high incidence of HCC; evolution time, cirrhosis and age over 51 appear to be the most important contributing factors.

摘要

为评估迟发性皮肤卟啉症（PCT）患者肝细胞癌（HCC）的发病率，我们对83例患者（77例男性，6例女性，平均年龄57.4岁）进行了研究。其中13例患者（15.7%）患有HCC，均为男性且患有肝硬化，平均年龄58.5岁。与未患HCC的患者（9.4年）相比，HCC患者从皮肤疾病发病起的病程时间更长（23年），差异具有统计学意义（P<0.0005），而两组患者的发病年龄相似。两组患者在酒精摄入量和乙肝病毒（HBV）标志物方面的差异无统计学意义，不过两组既往HBV感染的患病率均较高（54%）。在HCC发生过程中，肝硬化（P<0.001）、男性（P无统计学意义）以及年龄超过51岁（P<0.025）的归因风险均为100%。因此，PCT患者HCC的发病率较高；病程时间、肝硬化以及年龄超过51岁似乎是最重要的促成因素。