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1
Molecular basis of the dm1 mutation in the major histocompatibility complex of the mouse: a D/L hybrid gene.小鼠主要组织相容性复合体中dm1突变的分子基础：一个D/L杂交基因。
J Exp Med. 1985 Nov 1;162(5):1588-602. doi: 10.1084/jem.162.5.1588.
2
A molecular hybrid of the H-2Dd and H-2Ld genes expressed in the dm1 mutant.在dm1突变体中表达的H-2Dd和H-2Ld基因的分子杂种。
Proc Natl Acad Sci U S A. 1984 Aug;81(16):5204-8. doi: 10.1073/pnas.81.16.5204.
3
Introduction of H-2Dd determinants into the H-2Ld antigen by site-directed mutagenesis.通过定点诱变将H-2Dd决定簇引入H-2Ld抗原。
J Exp Med. 1987 Sep 1;166(3):744-60. doi: 10.1084/jem.166.3.744.
4
Expression of H-2Dd and H-2Ld mouse major histocompatibility antigen genes in L cells after DNA-mediated gene transfer.DNA介导的基因转移后，H-2Dd和H-2Ld小鼠主要组织相容性抗原基因在L细胞中的表达。
J Immunol. 1983 Jan;130(1):463-70.
5
Analysis of hybrid H-2D and L antigens with reciprocally mismatched aminoterminal domains: functional T cell recognition requires preservation of fine structural determinants.对具有相互错配氨基末端结构域的杂交H-2D和L抗原的分析：功能性T细胞识别需要保留精细结构决定簇。
J Immunol. 1986 Dec 15;137(12):3881-90.
6
Interaction of alpha 1 with alpha 2 region in class I MHC proteins contributes determinants recognized by antibodies and cytotoxic T cells.I类主要组织相容性复合体（MHC）蛋白中α1与α2区域的相互作用产生了可被抗体和细胞毒性T细胞识别的决定簇。
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7
Unexpected complexity of the dm1 mutation revealed in the structure of three H-2D/L-related antigens.在三种H-2D/L相关抗原的结构中揭示的dm1突变的意外复杂性。
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8
Structure and expression of a mouse major histocompatibility antigen gene, H-2Ld.小鼠主要组织相容性抗原基因H-2Ld的结构与表达
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The ability of H-2Dd molecule to affect natural resistance to hemopoietic allografts is an intrinsic property shared by Ddm1 but not Ld.H-2Dd分子影响对造血同种异体移植物天然抵抗力的能力是Ddm1所共有的内在特性，而Ld则没有。
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Expression and T cell recognition of hybrid antigens with amino-terminal domains encoded by Qa-2 region of major histocompatibility complex and carboxyl termini of transplantation antigens.具有由主要组织相容性复合体Qa-2区域编码的氨基末端结构域和移植抗原羧基末端的杂合抗原的表达及T细胞识别
J Exp Med. 1985 May 1;161(5):935-52. doi: 10.1084/jem.161.5.935.

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1
Mouse models of efficient and inefficient anti-tumor immunity, with emphasis on minimal residual disease and tumor escape.高效和低效抗肿瘤免疫的小鼠模型，重点关注微小残留病和肿瘤逃逸。
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2
A complex major histocompatibility complex D locus variant generated by an unusual recombination mechanism in mice.小鼠中由一种不寻常的重组机制产生的复杂主要组织相容性复合体D位点变体。
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The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand.自然杀伤细胞受体Ly-49A识别其主要组织相容性复合体I类配体上的肽诱导构象决定簇。
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FVB mice transgenic for the H-2Db gene become resistant to persistent infection by Theiler's virus.携带H-2Db基因的转基因FVB小鼠对泰勒氏病毒的持续感染产生抗性。
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5
Bat-1 genes and the origin of multiple class I loci in the H-2D region.Bat-1基因与H-2D区域多个I类基因座的起源
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6
Non-homologous recombination within the major histocompatibility complex creates a transcribed hybrid sequence.主要组织相容性复合体内的非同源重组产生一个转录的杂交序列。
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7
Amino acid sequence of the testosterone-regulated mouse kidney RP2 protein deduced from its complementary DNA sequence.从互补DNA序列推导的睾酮调节的小鼠肾脏RP2蛋白的氨基酸序列。
Nucleic Acids Res. 1986 Jul 11;14(13):5159-70. doi: 10.1093/nar/14.13.5159.
8
Organization and evolution of D region class I genes in the mouse major histocompatibility complex.小鼠主要组织相容性复合体中I类D区基因的组织与进化
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9
Structure and function of three novel MHC class I antigens derived from a C3H ultraviolet-induced fibrosarcoma.源自C3H紫外线诱导纤维肉瘤的三种新型MHC I类抗原的结构与功能
J Exp Med. 1986 Sep 1;164(3):794-813. doi: 10.1084/jem.164.3.794.
10
The murine MHC class I genes, H-2Dq and H-2Lq, are strikingly homologous to each other, H-2Ld, and two genes reported to encode tumor-specific antigens.小鼠主要组织相容性复合体I类基因H-2Dq和H-2Lq彼此之间、与H-2Ld以及另外两个据报道编码肿瘤特异性抗原的基因具有显著的同源性。
J Exp Med. 1988 Nov 1;168(5):1719-39. doi: 10.1084/jem.168.5.1719.

本文引用的文献

1
Immunochemical evidence in two haplotypes for at least three D region-encoded molecules, D, L, and R.在两个单倍型中存在至少三种D区域编码分子（D、L和R）的免疫化学证据。
J Immunol. 1981 May;126(5):1713-6.
2
DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen.编码BALB/c小鼠Ld移植抗原的基因的DNA序列。
Science. 1982 Feb 5;215(4533):679-82. doi: 10.1126/science.7058332.
3
Identification of a BALB/c H-2Ld gene by DNA-mediated gene transfer.通过DNA介导的基因转移鉴定BALB/c H-2Ld基因。
Science. 1982 Feb 5;215(4533):677-9. doi: 10.1126/science.7058331.
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The making of strand-specific M13 probes.链特异性M13探针的制备。
Gene. 1982 Mar;17(3):271-7. doi: 10.1016/0378-1119(82)90143-3.
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History and genealogy of the H-2Kb mutants from the C57BL/6Kh colony.来自C57BL/6Kh群体的H-2Kb突变体的历史和谱系。
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6
Biochemistry of the gene products from murine MHC mutants.小鼠主要组织相容性复合体（MHC）突变体基因产物的生物化学
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7
The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events.一个突变的H-2基因的结构表明，H-2基因多态性的产生可能是通过类似基因转换的事件发生的。
Nature. 1983 Feb 24;301(5902):671-4. doi: 10.1038/301671a0.
8
H-2bm23, a new Kb mutant similar to, but not identical with H-2bm3.H-2bm23，一种与H-2bm3相似但不相同的新型Kb突变体。
Immunogenetics. 1984;20(1):83-7. doi: 10.1007/BF00373449.
9
Two-dimensional gel comparisons of murine H-2D region-associated antigens of different H-2 haplotypes.不同H-2单倍型小鼠H-2D区域相关抗原的二维凝胶比较。
J Immunol. 1983 Nov;131(5):2440-4.
10
Spontaneous H-2 mutants provide evidence that a copy mechanism analogous to gene conversion generates polymorphism in the major histocompatibility complex.自发的H-2突变体提供了证据，表明一种类似于基因转换的复制机制在主要组织相容性复合体中产生了多态性。
Proc Natl Acad Sci U S A. 1983 Jan;80(1):242-6. doi: 10.1073/pnas.80.1.242.

小鼠主要组织相容性复合体中dm1突变的分子基础：一个D/L杂交基因。

Molecular basis of the dm1 mutation in the major histocompatibility complex of the mouse: a D/L hybrid gene.

作者信息

Sun Y H, Goodenow R S, Hood L

出版信息

J Exp Med. 1985 Nov 1;162(5):1588-602. doi: 10.1084/jem.162.5.1588.

DOI:10.1084/jem.162.5.1588
PMID:2997361
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187929/
Abstract

The H-2dm1 mutation is unique among all described H-2 mutations in that two transplantation antigens, the H-2Dd and the H-2Ld, are affected. Here, we show that the mutant gene, Ddm1, is formed by fusion of the 5' part of the Dd gene and the 3' part of the Ld gene, with the region in between deleted. The recombination junction is located in the third exon, which encodes the alpha 2 region of the protein. When the hybrid gene is transfected into mouse L cells, serological and biochemical analyses indicate the Ddm1 antigen expressed in the transformant line is identical to the mutant molecule in dm1 spleen cells. These results demonstrate that the D/L hybrid gene is most likely responsible for the dm1 mutant phenotype.

摘要

H-2dm1突变在所有已描述的H-2突变中是独特的，因为两种移植抗原H-2Dd和H-2Ld受到影响。在此，我们表明突变基因Ddm1是由Dd基因的5'部分与Ld基因的3'部分融合形成的，中间区域缺失。重组连接点位于第三个外显子，该外显子编码蛋白质的α2区域。当将杂交基因转染到小鼠L细胞中时，血清学和生化分析表明转化细胞系中表达的Ddm1抗原与dm1脾细胞中的突变分子相同。这些结果表明D/L杂交基因很可能是dm1突变表型的原因。