asperitaconic 酸 A-C，海洋来源的曲霉菌属真菌产生的具有抗菌活性的 itaconic 酸衍生物。
Asperitaconic acids A-C, antibacterial itaconic acid derivatives produced by a marine-derived fungus of the genus Aspergillus.
机构信息
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, 315211, Ningbo, China.
Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University, 315211, Ningbo, China.
出版信息
J Antibiot (Tokyo). 2018 Oct;71(10):902-904. doi: 10.1038/s41429-018-0079-2. Epub 2018 Jul 4.
Three new itaconic acid derivatives, asperitaconic acids A-C (1-3), were isolated from the ethyl acetate extracts of the rice fermentation of a marine-derived fungus Aspergillus niger, and asperitaconic acids A-C were characterized by an itaconic acid unit and an alkyl chain moiety. Their structures were established by interpretation of their spectroscopic data including NMR and HRESIMS. Asperitaconic acids A-C exhibited antibacterial effect against Staphylococcus aureus with MIC values of 16-32 μg/mL, whereas these compounds showed no cytotoxicity against HepG2 and HeLa cancer cell lines.
从海洋来源真菌黑曲霉的大米发酵的乙酸乙酯提取物中分离得到三种新的衣康酸衍生物，asperitaconic 酸 A-C（1-3），并通过其包括 NMR 和 HRESIMS 在内的光谱数据的解释来表征 asperitaconic 酸 A-C。asperitaconic 酸 A-C 对金黄色葡萄球菌表现出抗菌作用，MIC 值为 16-32μg/mL，而这些化合物对 HepG2 和 HeLa 癌细胞系没有细胞毒性。
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