Chu Andrew, Krishna Alvin, Paul Manju P, Sexton James F, Mirchia Kanish
Pulmonary and Critical Care Medicine, SUNY Upstate Medical University.
Internal medicine, SUNY Upstate Medical University.
Cureus. 2018 May 2;10(5):e2571. doi: 10.7759/cureus.2571.
Foreign body aspiration occurs in all age groups, especially in children and the elderly. The aspiration of an organic foreign body such as iron sulfate can cause significant bronchial destruction via oxidizing necrosis. When iron comes into contact with bronchial mucosa, it gets oxidized from ferrous ions into a ferric form which is highly toxic to the mucosa causing severe inflammation, mucosal damage, and fibrosis. Physicians should be very prudent with prescribing iron sulfate or any other pills in individuals who are at high risk of aspiration. Diagnosis is based on the history of iron aspiration, intense airway inflammation or necrosis on bronchoscopic examination, and iron particles observed on pathology. Prompt diagnosis and management should take place to prevent further morbidities. We report a case of 61-year-old female who was admitted to the hospital with a four-week history of aspirating iron pill. Computed tomography (CT) of the thorax showed ground glass infiltrates in the right lower lobe. She underwent flexible bronchoscopy which showed distal right bronchus intermedius (RBI) necrosis and stenosis with near-complete obstruction of distal RBI. She underwent multiple advanced bronchoscopic interventions with minimal improvement of the obliterated bronchus.
异物吸入发生于所有年龄组,尤其是儿童和老年人。吸入硫酸铁等有机异物可通过氧化坏死导致严重的支气管破坏。当铁与支气管黏膜接触时,它会从亚铁离子氧化成铁离子形式,这种形式对黏膜具有高度毒性,可导致严重炎症、黏膜损伤和纤维化。对于有高吸入风险的个体,医生在开具硫酸铁或任何其他药丸时应非常谨慎。诊断基于铁吸入史、支气管镜检查时的强烈气道炎症或坏死以及病理检查中观察到的铁颗粒。应及时进行诊断和处理以预防进一步的发病情况。我们报告一例61岁女性,因吸入铁丸四周入院。胸部计算机断层扫描(CT)显示右下叶磨玻璃样浸润。她接受了柔性支气管镜检查,结果显示右中间支气管(RBI)远端坏死和狭窄,RBI远端几乎完全阻塞。她接受了多次高级支气管镜干预,但闭塞支气管的改善甚微。