Department of Medical Microbiology, Sarab Faculty of Medical Sciences, Sarab, Iran.
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Helicobacter. 2018 Oct;23(5):e12511. doi: 10.1111/hel.12511. Epub 2018 Jul 4.
Infections with gastric Helicobacter spp. are associated with gastritis, peptic ulceration, and malignancies. Helicobacter pylori is the most prevalent Helicobacter species colonizing the human stomach. Other gastric non-H. pylori helicobacters (NHPHs) have been described in 0.2%-6% of human patients with gastric disorders. Nevertheless, due to difficulties in the diagnosis of NHPH infections and lack of routine screening, this is most likely an underestimation of their true prevalence. To the best of our knowledge, no studies have been performed in the presence of Helicobacter spp. in children suffering from gastric disorders in Southern Turkey.
In total, 110 children with gastric complaints were examined at the Cukurova University Balcali hospital, Turkey. Gastroscopy was performed to evaluate the presence of gastric mucosal lesions. Biopsies of the pyloric gland zone were taken for histopathological analysis, rapid urease testing, and presence of Helicobacter spp. DNA by PCR.
Based on the PCR results, the prevalence of Helicobacter spp. was 32.7% (36/110). H. pylori was found in 30.9% (34/110), H. suis in 1.8% (2/110), and H. heilmannii/H. ailurogastricus in 0.9% (1/110) of the human patients. A mixed infection with H. pylori and H. suis was present in one patient. The presence of mucosal abnormalities, such as nodular inflammation, ulceration, and hyperemia, as well as gastritis, was significantly higher in Helicobacter spp. positive patients.
Helicobacter pylori, H. suis, and H. heilmannii/H. ailurogastricus were present in children with gastric complaints. Infection with these pathogens may be involved in the development of gastritis and ulceration.
胃幽门螺旋杆菌感染与胃炎、消化性溃疡和恶性肿瘤有关。幽门螺杆菌是最常见的定植于人类胃内的幽门螺旋杆菌种。其他胃非幽门螺杆菌螺旋体（NHPH）在 0.2%-6%的有胃部疾病的人类患者中被描述过。然而，由于 NHPH 感染的诊断困难和缺乏常规筛查，这很可能是对其真实流行率的低估。据我们所知，在土耳其南部患有胃部疾病的儿童中，尚未进行过关于幽门螺旋杆菌属感染的研究。
在土耳其库鲁瓦大学巴奇利医院共检查了 110 名有胃部不适的儿童。进行胃镜检查以评估胃黏膜病变的存在。对幽门腺区进行活检，用于组织病理学分析、快速尿素酶检测和聚合酶链反应（PCR）检测幽门螺旋杆菌属 DNA 的存在。
根据 PCR 结果，幽门螺旋杆菌属的流行率为 32.7%（36/110）。在 110 名患者中，发现幽门螺杆菌 30.9%（34/110），猪幽门螺杆菌 1.8%（2/110），和 H.heilmannii/H.ailurogastricus 0.9%（1/110）。一名患者存在幽门螺杆菌和猪幽门螺杆菌混合感染。在幽门螺旋杆菌属阳性患者中，黏膜异常的存在，如结节性炎症、溃疡和充血，以及胃炎，显著更高。
在有胃部不适的儿童中存在幽门螺杆菌、猪幽门螺杆菌和 H.heilmannii/H.ailurogastricus。这些病原体的感染可能与胃炎和溃疡的发展有关。
