Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuernberg FAU, Erlangen, Germany.
Int Wound J. 2018 Dec;15(6):978-984. doi: 10.1111/iwj.12958. Epub 2018 Jul 4.
Microbial wound contamination is known to be a hindrance to wound healing. Negative pressure wound therapy (NPWT) with or without irrigation is known to optimise conditions in problem wounds. The aim of this study was to investigate the influence of computer-controlled wound irrigation with NPWT on the bacterial load in contaminated wounds. A total of 267 patients were treated with NPWT with automated instillation because of problematic wounds using an antiseptic instillation solution. In 111 patients, a minimum of 4 operative procedures were necessary, and swabs were taken at least at the first and at the fourth operation in a standardised procedure. The number of different bacteria and the amount of bacteria were analysed during the course. In a subgroup of 51 patients, swabs were taken at all 4 operative procedures and analysed separately. In an overall analysis, the number of different bacteria and the amount of bacteria significantly decreased independent of wound localisation and diagnosis. NPWT with automated instillation demonstrates a positive influence in the reduction of bacterial load in problem wounds. Thus, it may help to optimise wound conditions before definite wound closure.
微生物污染被认为是阻碍伤口愈合的一个因素。负压伤口治疗（NPWT）联合或不联合冲洗被认为可以优化问题伤口的条件。本研究旨在探讨计算机控制的伤口冲洗联合 NPWT 对污染伤口细菌负荷的影响。共有 267 例因问题伤口使用含防腐剂冲洗液而接受 NPWT 治疗的患者。在 111 例患者中，至少进行了 4 次手术，并且按照标准化程序，在第一次和第四次手术时至少取一次拭子。在整个过程中分析了不同细菌的数量和细菌数量。在 51 例患者的亚组中，在所有 4 次手术中均取拭子并分别进行分析。总体分析显示，不同细菌的数量和细菌数量均显著减少，与伤口位置和诊断无关。自动化冲洗 NPWT 对减少问题伤口的细菌负荷有积极影响。因此，它可能有助于在确定伤口闭合之前优化伤口条件。
