All India Institute of Medical Sciences, Rishikesh, 249203, India.
Banaras Hindu University, Varanasi, India.
Eur J Med Res. 2023 Apr 25;28(1):157. doi: 10.1186/s40001-023-01121-7.
The bubbling community of microorganisms, consisting of diverse colonies encased in a self-produced protective matrix and playing an essential role in the persistence of infection and antimicrobial resistance, is often referred to as a biofilm. Although apparently indolent, the biofilm involves not only inanimate surfaces but also living tissue, making it truly ubiquitous. The mechanism of biofilm formation, its growth, and the development of resistance are ever-intriguing subjects and are yet to be completely deciphered. Although an abundance of studies in recent years has focused on the various ways to create potential anti-biofilm and antimicrobial therapeutics, a dearth of a clear standard of clinical practice remains, and therefore, there is essentially a need for translating laboratory research to novel bedside anti-biofilm strategies that can provide a better clinical outcome. Of significance, biofilm is responsible for faulty wound healing and wound chronicity. The experimental studies report the prevalence of biofilm in chronic wounds anywhere between 20 and 100%, which makes it a topic of significant concern in wound healing. The ongoing scientific endeavor to comprehensively understand the mechanism of biofilm interaction with wounds and generate standardized anti-biofilm measures which are reproducible in the clinical setting is the challenge of the hour. In this context of "more needs to be done", we aim to explore various effective and clinically meaningful methods currently available for biofilm management and how these tools can be translated into safe clinical practice.
由多种微生物菌落组成的、能自我产生保护基质的、在感染持续存在和抗菌药物耐药中起关键作用的微生物群落，通常被称为生物膜。尽管生物膜看起来很惰性，但它不仅存在于无生命的表面，也存在于活组织中，因此它无处不在。生物膜形成的机制、生长和耐药性的发展一直是令人着迷的课题，目前尚未完全破解。尽管近年来大量研究集中在开发潜在的抗生物膜和抗菌治疗方法上，但仍缺乏明确的临床实践标准，因此，将实验室研究转化为新型床边抗生物膜策略，以提供更好的临床效果，这是非常必要的。值得注意的是，生物膜是导致伤口愈合不良和慢性化的原因。实验研究报告称，慢性伤口中生物膜的存在率在 20%到 100%之间，这使其成为伤口愈合中一个非常值得关注的问题。目前，科学界正在努力全面了解生物膜与伤口相互作用的机制，并制定出可在临床环境中重现的标准化抗生物膜措施，这是当前的挑战。在“需要做更多工作”的背景下，我们旨在探讨目前可用于生物膜管理的各种有效且具有临床意义的方法，以及这些工具如何转化为安全的临床实践。
