Dadaş Erdoğan, Aydın Muhsin
Department of Thoracic Surgery, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.
Department of Biology, Faculty of Science and Letters, Adiyaman University, Adiyaman, Turkey.
Cell Mol Biol (Noisy-le-grand). 2018 May 30;64(7):97-102.
Overexpression of Hox transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is associated with tumorigenesis and multiple cancer types including lung cancer. In this study, the association between two HOTAIR single nucleotide polymorphisms (SNPs) (rs12826786 and rs1899663) on the risk and clinical characteristics of lung cancer in a Turkish population was investigated. We genotyped HOTAIR rs12826786 and rs1899663 polymorphisms in 180 Turkish people including 87 lung cancer patients (71 males and 16 females) and 93 age-matched healthy controls (67 males and 26 females) by a TaqMan real-time polymerase chain reaction method. The mean age value of the lung cancer patients and control subjects were 59.27 ± 10.55 and 61.77 ± 12.00, respectively. We found that none of the two HOTAIR polymorphisms (rs12826786 T>C, rs1899663A>C) has any significant association with the increased risk of lung cancer in any type of inheritance genetic models. However, our research indicated that carriers of Trs12826786/Crs1899663 (ht3) (P = 0.03) had an increased risk of lung cancer susceptibility.
Hox转录本反义基因间RNA（HOTAIR）是一种长链非编码RNA（lncRNA），其过表达与肿瘤发生及包括肺癌在内的多种癌症类型相关。在本研究中，调查了土耳其人群中两个HOTAIR单核苷酸多态性（SNP）（rs12826786和rs1899663）与肺癌风险及临床特征之间的关联。我们采用TaqMan实时聚合酶链反应方法，对180名土耳其人（包括87例肺癌患者（71例男性和16例女性）和93名年龄匹配的健康对照（67例男性和26例女性））的HOTAIR rs12826786和rs1899663多态性进行基因分型。肺癌患者和对照受试者的平均年龄值分别为59.27±10.55和61.77±12.00。我们发现，在任何类型的遗传模型中，两个HOTAIR多态性（rs12826786 T>C、rs1899663A>C）均与肺癌风险增加无显著关联。然而，我们的研究表明，Trs12826786/Crs1899663（ht3）携带者患肺癌易感性增加（P = 0.03）。
